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注射吸毒者中丙型肝炎的预防:可能的保护措施类型

Hepatitis C avoidance in injection drug users: a typology of possible protective practices.

作者信息

McGowan Catherine, Harris Magdalena, Rhodes Tim

机构信息

Department of Social and Environmental Health Research, London School of Hygiene & Tropical Medicine, London, United Kingdom.

出版信息

PLoS One. 2013 Oct 23;8(10):e77038. doi: 10.1371/journal.pone.0077038. eCollection 2013.

Abstract

INTRODUCTION

Hepatitis C virus (HCV) represents a serious public health concern. People who inject drugs (PWID) are at particular risk and nearly half (45%) of PWID in England may be infected. HCV prevention interventions have only had moderate impact on the prevalence of HCV in this population. Using qualitative methods, we sought to detail the protective practices potentially linked to HCV avoidance among PWID, and explore the motivations for these.

METHODS

The study used a life history approach allowing participants to detail their lived experience both before and during the course of their injecting careers. Thirty-seven participants were recruited from drug services in London, and from referrals within local injecting networks. A baseline and follow-up in-depth qualitative interview was carried out with each participant, and for half, a third interview was also undertaken. All underwent testing for HCV antibody. Analyses focused on developing a descriptive typology of protective practices potentially linked to HCV avoidance.

RESULTS

Practices were deemed to be protective against HCV if they could be expected a priori to reduce the number of overall injections and/or the number of injections using shared injecting equipment. Participants reported engaging in various protective practices which fell into three categories identified through thematic analysis: principles about injecting, preparedness, and flexibility.

CONCLUSIONS

All participants engaged in protective practices irrespective of serostatus. It is important to consider the relative importance of different motivations framing protective practices in order to formulate harm reduction interventions which appeal to the situated concerns of PWID, especially given that these protective practices may also help protect against HIV and other blood borne infections.

摘要

引言

丙型肝炎病毒(HCV)是一个严重的公共卫生问题。注射吸毒者(PWID)面临特别高的风险,在英国,近一半(45%)的注射吸毒者可能受到感染。丙型肝炎病毒预防干预措施对该人群中丙型肝炎病毒的流行率仅产生了中等程度的影响。我们采用定性方法,试图详细了解与注射吸毒者避免感染丙型肝炎病毒潜在相关的保护行为,并探究其背后的动机。

方法

本研究采用生活史方法,让参与者详细描述他们在注射吸毒生涯之前和期间的生活经历。从伦敦的毒品服务机构以及当地注射网络的转介人员中招募了37名参与者。对每位参与者进行了一次基线和随访深度定性访谈,其中一半参与者还进行了第三次访谈。所有参与者都接受了丙型肝炎病毒抗体检测。分析重点在于构建一种与避免感染丙型肝炎病毒潜在相关的保护行为描述类型。

结果

如果某些行为能够事先预期减少总体注射次数和/或使用共用注射设备的注射次数,那么这些行为就被认为对丙型肝炎病毒具有保护作用。参与者报告了各种保护行为,通过主题分析可分为三类:注射原则、准备工作和灵活性。

结论

所有参与者,无论血清学状态如何,都采取了保护行为。考虑不同动机对保护行为的相对重要性,对于制定能引起注射吸毒者实际关注的减少伤害干预措施很重要,特别是鉴于这些保护行为也可能有助于预防艾滋病毒和其他血源性感染。

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