Richter J A, Barankay A, Göb E, Späth P
J Cardiovasc Pharmacol. 1986 Jan-Feb;8(1):109-15. doi: 10.1097/00005344-198601000-00017.
The cardiovascular effects of ketanserin (5-HT2-receptor antagonist with alpha 1-receptor blocking property) were studied during coronary artery surgery. Sixteen patients were anesthetized with flunitrazepamfentanyl-nitrous oxide-oxygen-pancuronium. Ketanserin (10 mg i.v.) was used to decrease elevated blood pressure unresponsive to deepening of anesthesia before extracorporeal circulation. Ketanserin caused a marked vasodilation in all patients, significant (p less than 0.05) decreases of systolic, diastolic, and mean arterial blood pressure, and of pulmonary artery pressure and pulmonary capillary wedge pressure. As a result, indirect indices of myocardial oxygen demand (rate-pressure product and "triple index") also decreased. Heart rate and right atrial pressure remained unchanged, while cardiac index and stroke volume index increased slightly. Ketanserin was found to be effective in the treatment of prebypass hypertension; the elevated blood pressure returned to normal; unwanted hypotension was not observed.
在冠状动脉手术期间研究了酮色林（一种具有α1受体阻断特性的5 - HT2受体拮抗剂）的心血管效应。16例患者采用氟硝西泮 - 芬太尼 - 氧化亚氮 - 氧气 - 泮库溴铵麻醉。在体外循环前，使用酮色林（静脉注射10毫克）来降低对加深麻醉无反应的血压升高。酮色林在所有患者中均引起明显的血管舒张，收缩压、舒张压、平均动脉压、肺动脉压和肺毛细血管楔压均显著降低（p < 0.05）。结果，心肌氧需求的间接指标（心率 - 血压乘积和“三联指数”）也降低。心率和右心房压力保持不变，而心脏指数和每搏量指数略有增加。发现酮色林在治疗体外循环前高血压方面有效；升高的血压恢复正常；未观察到不良低血压。
