Department of Experimental and Clinical Sciences, University 'G. d'Annunzio', I-66013 Chieti, Italy.
Cancers (Basel). 2013 Jul 25;5(3):919-42. doi: 10.3390/cancers5030919.
Hydroxamate-based histone deacetylase inhibitors (Hb-HDACIs), such as vorinostat, belinostat and panobinostat, have been previously shown to have a wide range of activity in hematologic malignancies such as cutaneous T-cell lymphoma and multiple myeloma. Recent data show that they synergize with a variety of cytotoxic and molecular targeted agents in many different solid tumors, including breast, prostate, pancreatic, lung and ovarian cancer. Hb-HDACIs have a quite good toxicity profile and are now being tested in phase I and II clinical trials in solid tumors with promising results in selected neoplasms, such as hepatocarcinoma. This review will focus on their clinical activity and safety in patients with advanced solid neoplasms.
基于羟肟酸的组蛋白去乙酰化酶抑制剂(Hb-HDACIs),如伏立诺他、贝利司他和帕比司他,先前已显示在血液系统恶性肿瘤中具有广泛的活性,如皮肤 T 细胞淋巴瘤和多发性骨髓瘤。最近的数据表明,它们在许多不同的实体瘤中与多种细胞毒性和分子靶向药物具有协同作用,包括乳腺癌、前列腺癌、胰腺癌、肺癌和卵巢癌。Hb-HDACIs 的毒性特征相当好,目前正在实体瘤的 I 期和 II 期临床试验中进行测试,在某些肿瘤(如肝癌)中取得了有前景的结果。这篇综述将重点关注它们在晚期实体瘤患者中的临床活性和安全性。