[结节病的遗传风险概况]

[Genetic risk profile of sarcoidosis].

作者信息

Fischer A, Zissel G, Nebel A, Müller-Quernheim J

机构信息

Institut für Klinische Molekularbiologie, Christian-Albrechts-Universität, Kiel, Deutschland.

出版信息

Internist (Berl). 2014 Feb;55(2):135-40. doi: 10.1007/s00108-013-3308-6.

DOI:10.1007/s00108-013-3308-6

PMID:24217528

Abstract

Sarcoidosis is a multifactorial and polygenic disorder. The current knowledge of its genetic basis will be presented and functional consequences of the genetic variants that influence the immunopathogenesis of this disorder will be depicted. In the near future it is expected that this knowledge will yield clinically applicable genetic risk profiles.

摘要

结节病是一种多因素和多基因疾病。本文将介绍其遗传基础的现有知识，并描述影响该疾病免疫发病机制的基因变异的功能后果。在不久的将来，预计这些知识将产生临床适用的遗传风险概况。