[龙胆苦苷与龙胆提取物在大鼠体内的药代动力学比较研究]

[Comparative study on pharmacokinetics of gentiopicroside and gentianae radix extract in rats].

作者信息

Feng Bo, Zhu He-Yun, Guan Jiao, Hao Cheng-Yi, Duan Jing-Can, Gu Jing-Kai

机构信息

College of Pharmacy,Jilin Medical College, Jilin 132013, China.

出版信息

Zhong Yao Cai. 2013 May;36(5):783-6.

PMID:24218974

Abstract

OBJECTIVE

To compare the pharmacokinetics of gentiopicroside and Gentianae Radix extract in rats and assess the effect of other components in Gentianae Radix on the pharmacokinetics of gentiopicroside.

METHODS

The rats were oral administrated with gentiopicroside and Gentianae Radix extract, the content of geritiopicroside was chosen as index and determined by HPLC. The pharmacokinetic parameters were calculated with DAS 2.1.1 program.

RESULTS

The concentration-time curve of gentiopicroside and Gentianae Radix extract was described by two compartment model. The main pharmacokinetic parameters of gentiopicroside and Gentianae Radix extract were: C(max) (16.53 +/- 0.37) g/mL and (16.61 +/- 0.49) g/mL, T(max) 0.25 h and 1.5 h, t1/2(alpha) (0.20 +/- 0.04) h and (0.69 +/- 0. 14) h, t /2 (beta) (0.64 +/- 0.08) hand (0.80 +/- 0.11) h, AUC(0-infinity) (18.20 +/- 1.97) g x h/mL and (39.20 +/- 1.18) g x h/mL, CL( 2.75 +/- 0.32) L/(h x kg) and (1.22 +/- 0.04) L (h x kg), respectively.

CONCLUSION

There are significantly differences in pharmacokinetic parameters between gentiopicroside and Gentianae Radix extract in rats.

摘要

目的

比较龙胆苦苷与龙胆提取物在大鼠体内的药代动力学，并评估龙胆中其他成分对龙胆苦苷药代动力学的影响。

方法

大鼠口服给予龙胆苦苷和龙胆提取物，以龙胆苦苷含量为指标，采用高效液相色谱法测定。用DAS 2.1.1程序计算药代动力学参数。

结果

龙胆苦苷和龙胆提取物的浓度-时间曲线均符合二室模型。龙胆苦苷和龙胆提取物的主要药代动力学参数分别为：C(max) (16.53±0.37) μg/mL和(16.61±0.49) μg/mL，T(max) 0.25 h和1.5 h，t1/2(α) (0.20±0.04) h和(0.69±0.14) h，t1/2(β) (0.64±0.08) h和(0.80±0.11) h，AUC(0-∞) (18.20±1.97) μg·h/mL和(39.20±1.18) μg·h/mL，CL(2.75±0.32) L/(h·kg)和(1.22±0.04) L/(h·kg)。