Matsuda Satoru, Nakanishi Atsuko, Wada Yoko, Kitagishi Yasuko
Department of Food Science and Nutrition, Nara Women's University, Kita-Uoya Nishimachi, Nara 630-8506, Japan.
Open Med Chem J. 2013 Oct 31;7:23-9. doi: 10.2174/1874104501307010023. eCollection 2013.
Multiple enzymes participate in the phosphorylation of a group of phosphoinositide lipids. Because of their important role in signal transduction, the dysregulated metabolism of phosphoinositides represents a key step in many disease settings. Loss of their function has been demonstrated to occur as an early event a wide variety of carcinogenesis and has therefore been suggested as a biomarker for the premalignant disease. In addition, genetic alterations at multiple nodes in the pathway have been implicated in several other diseases. Accordingly, given this pervasive involvement in many diseases, the development of molecules that modulates this pathway has been initiated in studies. They have been the focus of extensive research and drug discovery activities. A better understanding of the molecular connections could uncover new targets for drug development.
多种酶参与一组磷酸肌醇脂质的磷酸化过程。由于它们在信号转导中发挥重要作用，磷酸肌醇代谢失调是许多疾病发生过程中的关键步骤。已证明其功能丧失是多种癌症发生过程中的早期事件，因此被认为是癌前疾病的生物标志物。此外，该信号通路多个节点的基因改变与其他几种疾病有关。因此，鉴于其在多种疾病中的广泛参与，目前已开始研究开发调节该信号通路的分子。它们一直是广泛研究和药物研发活动的重点。对分子间联系的深入了解可能会揭示药物开发的新靶点。
