United BioSource Corporation, Science Policy, Bethesda, MD, USA.
J Comp Eff Res. 2012 Sep;1(5):431-40. doi: 10.2217/cer.12.41.
To develop principles for planning and conducting comparative effectiveness research (CER).
Beginning with a modified existing list of health technology assessment principles, we developed a set of CER principles using literature review, engagement of multiple experts and broad stakeholder feedback.
RESULTS & CONCLUSION: Thirteen principles and actions to fulfill their intent are proposed. Principles include clarity of objectives, transparency, engagement of stakeholders, consideration of relevant perspectives, use of relevant comparators, and evaluation of relevant outcomes and treatment heterogeneity. Should these principles be found appropriate and useful, CER studies should be audited for adherence to them and monitored for their impact on care management, patient relevant outcomes and clinical guidelines.
制定规划和开展药物比较效果研究的原则。
从修改后的现有卫生技术评估原则清单开始,我们通过文献回顾、多方专家参与以及广泛的利益相关者反馈,制定了一套药物比较效果研究原则。
提出了 13 项原则和行动来实现其意图。这些原则包括目标明确、透明、利益相关者参与、考虑相关观点、使用相关对照、评估相关结果和治疗异质性。如果这些原则被认为是适当和有用的,那么应该对药物比较效果研究进行审核,以确保其遵循这些原则,并监测其对医疗管理、患者相关结果和临床指南的影响。