天然 botrydial 前体类似物的合成及抗真菌活性。

Synthesis and antifungal activity of analogues of naturally occurring botrydial precursors.

机构信息

Departamento de Química Orgánica Facultad de Ciencias, Universidad de Cádiz, Apdo. 40, 11510, Puerto Real, Cádiz, Spain.

出版信息

J Chem Ecol. 1994 Oct;20(10):2631-44. doi: 10.1007/BF02036197.

DOI:10.1007/BF02036197

PMID:24241837

Abstract

Analog compounds of the proposed intermediates of the biogenetic pathway to botrydial have been synthesized. These compounds were tested for their potential antifungal activity against the phytopathogenBotrytis cinerea. Our results showed a fungistatic effect of some compounds on mycelium growth. The most significant effect was exerted by 2-α-hydroxy-2,3-dihydro-1-epiprobotrydial, which inhibited growth ofB. cinerea. Some aspects of structure-activity relationships are discussed.

摘要

已经合成了提议的生物合成途径中间产物的类似物。这些化合物被测试了它们对植物病原菌Botrytis cinerea 的潜在抗真菌活性。我们的结果表明，一些化合物对菌丝生长具有抑菌作用。最显著的效果是由 2-α-羟基-2,3-二氢-1-表博来霉素引起的，它抑制了 B. cinerea 的生长。讨论了一些结构-活性关系的方面。