Aix-Marseille Université; Marseille, France ; Institut National de la Santé et de la Recherche Médicale; Centre de Recherche en Cancérologie de Marseille; Marseille, France ; Institut Paoli Calmettes; IBiSA Cancer Immunomonitoring Platform; Marseille, France.
Oncoimmunology. 2013 Sep 1;2(9):e25853. doi: 10.4161/onci.25853. Epub 2013 Jul 29.
Although in the last few years γδ T lymphocytes have been the subject of growing interest as potential anticancer immunotherapeutics, how the proliferative and effector responses of these cells are regulated remains unclear. We have recently reported that the co-receptor B and T lymphocyte associated (BTLA) inhibits the proliferation of human Vγ9Vδ2 T cells, potentially underpinning a mechanism of immune escape by lymphoma cells.
虽然在过去几年中,γδ T 淋巴细胞作为潜在的抗癌免疫治疗药物引起了越来越多的关注,但这些细胞的增殖和效应反应如何受到调节仍不清楚。我们最近报道称,共受体 B 和 T 淋巴细胞相关(BTLA)抑制人 Vγ9Vδ2 T 细胞的增殖,这可能为淋巴瘤细胞的免疫逃逸机制提供了基础。