Sadeh Sadra, Rotter Stefan
Bernstein Center Freiburg, Faculty of Biology, University of Freiburg, Hansastr. 9a, 79104 , Freiburg, Germany,
Biol Cybern. 2014 Oct;108(5):631-53. doi: 10.1007/s00422-013-0576-0. Epub 2013 Nov 19.
Orientation maps are a prominent feature of the primary visual cortex of higher mammals. In macaques and cats, for example, preferred orientations of neurons are organized in a specific pattern, where cells with similar selectivity are clustered in iso-orientation domains. However, the map is not always continuous, and there are pinwheel-like singularities around which all orientations are arranged in an orderly fashion. Although subject of intense investigation for half a century now, it is still not entirely clear how these maps emerge and what function they might serve. Here, we suggest a new model of orientation selectivity that combines the geometry and statistics of clustered thalamocortical afferents to explain the emergence of orientation maps. We show that the model can generate spatial patterns of orientation selectivity closely resembling the maps found in cats or monkeys. Without any additional assumptions, we further show that the pattern of ocular dominance columns is inherently connected to the spatial pattern of orientation.
朝向地图是高等哺乳动物初级视觉皮层的一个显著特征。例如,在猕猴和猫中,神经元的偏好朝向以特定模式组织,具有相似选择性的细胞聚集在等朝向区域。然而,该地图并不总是连续的,存在类似风车的奇点,所有朝向围绕这些奇点有序排列。尽管半个世纪以来一直是深入研究的对象,但这些地图是如何出现的以及它们可能发挥什么功能仍不完全清楚。在这里,我们提出了一种新的朝向选择性模型,该模型结合了聚集的丘脑皮质传入纤维的几何结构和统计数据来解释朝向地图的出现。我们表明,该模型可以生成与在猫或猴子中发现的地图非常相似的朝向选择性空间模式。在没有任何额外假设的情况下,我们进一步表明,眼优势柱的模式与朝向的空间模式有着内在联系。