Jones C R, Hamilton C A, Deighton N, Reid J L
J Cardiovasc Pharmacol. 1986 May-Jun;8(3):562-6. doi: 10.1097/00005344-198605000-00020.
The effects of perinephritis hypertension on lymphocyte and cardiac beta-adrenoceptors in the rabbit were examined. Hypertensive animals 8-12 weeks after surgery had an increase in cardiac weight consistent with hypertrophy compared with sham-operated age-matched controls. Specific binding of [I125] iodocyanopindolol (ICYP) to cardiac ventricular membranes was reduced in the hypertensive animals (Bmax44 +/- 14 in hypertensives and 30 +/- 15 fmoles/mg protein in controls; p less than 0.01). However, weight-matched ventricles from a group of older sham-operated normotensive rabbits showed a similar cardiac beta-receptor number to that found in the hypertensive animals. There were no changes in affinity of the ligand for the binding site. The reduction in cardiac beta-receptor density was not accompanied by changes in the chronotropic or blood pressure responses to isoprenaline in the conscious animal. Specific ICYP binding to lymphocyte beta-receptors did not differ significantly between the hypertensive and age-matched normotensive animals. Lymphocyte beta-adrenoceptors thus may not always reflect changes in heart beta-adrenoceptors, and changes in receptor density may not be directly related to blood pressure or have identifiable functional significance.
研究了兔肾盂肾炎高血压对淋巴细胞及心脏β肾上腺素能受体的影响。与假手术的年龄匹配对照组相比，术后8 - 12周的高血压动物心脏重量增加，符合心肌肥厚表现。高血压动物心脏心室膜上[I125]碘氰吲哚洛尔（ICYP）的特异性结合减少（高血压组Bmax为44±14，对照组为30±15 fmol/mg蛋白；p<0.01）。然而，一组年龄较大的假手术正常血压兔的重量匹配心室显示出与高血压动物相似的心脏β受体数量。配体与结合位点的亲和力没有变化。清醒动物心脏β受体密度降低并未伴随对异丙肾上腺素变时或血压反应的改变。高血压动物与年龄匹配的正常血压动物之间，ICYP与淋巴细胞β受体的特异性结合无显著差异。因此，淋巴细胞β肾上腺素能受体可能并不总是反映心脏β肾上腺素能受体的变化，受体密度的变化可能与血压无直接关系或具有可识别的功能意义。
