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致病性真菌生物膜的研究亮点

Highlights in pathogenic fungal biofilms.

作者信息

Sardi Janaina De Cássia Orlandi, Pitangui Nayla De Souza, Rodríguez-Arellanes Gabriela, Taylor Maria Lucia, Fusco-Almeida Ana Maria, Mendes-Giannini Maria José Soares

机构信息

Department of Clinical Analysis, Laboratory of Clinical Mycology, Faculty of Pharmaceutical Sciences, Universidade Estadual Paulista (UNESP), Araraquara, São Paulo, Brazil.

Fungal Immunology Laboratory, Department of Microbiology and Parasitology, School of Medicine, National Autonomous University of Mexico (UNAM), Mexico City, Mexico.

出版信息

Rev Iberoam Micol. 2014 Jan-Mar;31(1):22-9. doi: 10.1016/j.riam.2013.09.014. Epub 2013 Nov 16.

Abstract

A wide variety of fungi have demonstrated the ability to colonize surfaces and form biofilms. Most studies on fungal biofilms have focused on Candida albicans and more recently, several authors have reported the involvement of other genera of yeasts and Candida species, as well as of filamentous fungi in the formation of biofilms, including: Cryptococcus neoformans, Cryptococcus gattii, Rhodotorula species, Aspergillus fumigatus, Malassezia pachydermatis, Histoplasma capsulatum, Paracoccidioides brasiliensis, Pneumocystis species, Coccidioides immitis, Fusarium species, Saccharomyces cerevisiae, Trichosporon asahii, Mucorales and Blastoschizomyces. There is a current interest in describing the particular characteristics of the biofilm formation by of these fungi. A major concern is the control of biofilms, requiring knowledge of the biofilm mechanisms. However, our knowledge of these microbial communities is limited, due to the complexity of these systems and metabolic interactions that remain unknown. This mini-review aims to highlight recently discovered fungal biofilms and to compare them with the current knowledge on biofilms. This manuscript is part of the series of works presented at the "V International Workshop: Molecular genetic approaches to the study of human pathogenic fungi" (Oaxaca, Mexico, 2012).

摘要

各种各样的真菌已显示出在表面定殖并形成生物膜的能力。大多数关于真菌生物膜的研究都集中在白色念珠菌上,最近,几位作者报告了其他酵母属和念珠菌属物种以及丝状真菌参与生物膜的形成,包括:新型隐球菌、格特隐球菌、红酵母属、烟曲霉、厚皮马拉色菌、荚膜组织胞浆菌、巴西副球孢子菌、肺孢子菌属、粗球孢子菌、镰刀菌属、酿酒酵母、阿萨希毛孢子菌、毛霉目和芽裂酵母。目前人们对描述这些真菌形成生物膜的特殊特征很感兴趣。一个主要问题是生物膜的控制,这需要了解生物膜的机制。然而,由于这些系统的复杂性以及仍不清楚的代谢相互作用,我们对这些微生物群落的了解有限。本综述旨在强调最近发现的真菌生物膜,并将它们与当前关于生物膜的知识进行比较。本手稿是在“第五届国际研讨会:人类致病真菌研究的分子遗传学方法”(2012年,墨西哥瓦哈卡)上发表的系列作品的一部分。

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