吸烟者红细胞渗透脆性随血清晚期糖基化终末产物增加而升高。
Erythrocyte osmotic fragility increases with serum advanced glycated end products in cigarette smokers.
作者信息
Li Rulin, Chen Xuyang
机构信息
Laboratory for Development, College of Life Sciences, Northwest University, Xi'an Shaanxi, China National Engineering Research Center for Miniaturized Detection System, Northwest University, Xi'an Shaanxi, China.
College of Pharmaceutical Sciences, Chongqing Medical University, Chongqing, China.
出版信息
Clin Hemorheol Microcirc. 2014;57(1):85-92. doi: 10.3233/CH-131801.
BACKGROUND
This study examines the relationship between circulating advanced glycated end products (AGEs) level and erythrocyte osmotic fragility in smokers.
METHODS
Forty-eight smokers (aged 45 ± 5 years) and fifty healthy nonsmokers (aged 42 ± 6 years) were selected in this study. All subjects were analysed according to serum AGEs, osmotic fragility (H50, the NaCL concentration producing 50% hemolysis), malondialdehyde (MDA) and advanced oxidation protein products (AOPP).
RESULTS
The data show that the serum AGEs, H50, MDA and AOPP levels were significantly higher for smokers than that of nonsmokers (p < 0.01). The serum AGEs correlated with H50 in smokers (r = 0.7703, p < 0.01). MDA levels correlated with H50 in smokers (r = 0.7584, p < 0.01).
CONCLUSIONS
This study demonstrated that serum AGEs and MDA levels positively correlated with osmotic fragility in smokers.
背景
本研究探讨吸烟者循环中晚期糖基化终末产物（AGEs）水平与红细胞渗透脆性之间的关系。
方法
本研究选取了48名吸烟者（年龄45±5岁）和50名健康非吸烟者（年龄42±6岁）。根据血清AGEs、渗透脆性（H50，产生50%溶血的氯化钠浓度）、丙二醛（MDA）和晚期氧化蛋白产物（AOPP）对所有受试者进行分析。
结果
数据显示，吸烟者的血清AGEs、H50、MDA和AOPP水平显著高于非吸烟者（p<0.01）。吸烟者血清AGEs与H50相关（r=0.7703，p<0.01）。吸烟者MDA水平与H50相关（r=0.7584，p<0.01）。
结论
本研究表明，吸烟者血清AGEs和MDA水平与渗透脆性呈正相关。
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