Ohta Nobuo, Fukase Shigeru, Suzuki Yusuke, Kurakami Kazuya, Aoyagi Masaru, Kakehata Seiji
Department of Otolaryngology, Head and Neck Surgery, Yamagata University Faculty of Medicine , Yamagata , Japan.
Acta Otolaryngol. 2014 Feb;134(2):206-10. doi: 10.3109/00016489.2013.847285. Epub 2013 Nov 21.
Our results confirmed that OK-432 therapy is simple, easy, safe, and effective and can be used as a substitute for surgery in the treatment of ranula extending to the parapharyngeal space.
The aim of this study was to evaluate the outcome and complications of the OK-432 treatment of patients with ranula extending to the parapharyngeal space.
This was a case series with planned data collection at Yamagata University and Fukase clinic. We tried this therapy in six patients with ranula extending to the parapharyngeal space, between January 2001 and February 2012. We injected OK-432 solution into the lesion with an 18 or 27 gauge needle depending on the patient's condition (location and size of ranula and complications). This treatment was performed on an outpatient basis without hospitalization.
Disappearance or marked reduction of the lesion were observed in all patients who had this therapy, and local scarring and deformity of the injection sites did not occur in any patients. As side effects, local pain at the injection site and fever (37-39°C) were observed in 40% of the patients who had this therapy, but such problems resolved within a few days.
我们的结果证实，溶链菌制剂疗法简单、易行、安全且有效，可作为手术的替代方法用于治疗延伸至咽旁间隙的舌下囊肿。
本研究旨在评估溶链菌制剂治疗延伸至咽旁间隙的舌下囊肿患者的疗效及并发症。
这是一项在山形大学和深濑诊所进行计划数据收集的病例系列研究。2001年1月至2012年2月期间，我们对6例延伸至咽旁间隙的舌下囊肿患者尝试了这种疗法。根据患者情况（舌下囊肿的位置、大小及并发症），我们用18号或27号针头将溶链菌制剂溶液注入病变部位。该治疗在门诊进行，无需住院。
接受该疗法的所有患者均出现病变消失或明显缩小，且无任何患者出现注射部位局部瘢痕形成及畸形。作为副作用，40%接受该疗法的患者出现注射部位局部疼痛及发热（37 - 39°C），但这些问题在数天内得到解决。
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