Unit for Laboratory Animal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA, Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA, Center for Computational Medicine and Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA, Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA, Division of Comparative Medicine, University of South Florida, Tampa, FL 33612, USA, Department of Neurology, University of Michigan, 48109, Ann Arbor, MI, USA, College of Literature, Science, and the Arts, University of Michigan, Ann Arbor, MI 48109, USA, Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA and Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Nucleic Acids Res. 2014 Jan;42(Database issue):D1124-32. doi: 10.1093/nar/gkt1133. Epub 2013 Nov 19.
The integrative Vaccine Investigation and Online Information Network (VIOLIN) vaccine research database and analysis system (http://www.violinet.org) curates, stores, analyses and integrates various vaccine-associated research data. Since its first publication in NAR in 2008, significant updates have been made. Starting from 211 vaccines annotated at the end of 2007, VIOLIN now includes over 3240 vaccines for 192 infectious diseases and eight noninfectious diseases (e.g. cancers and allergies). Under the umbrella of VIOLIN, >10 relatively independent programs are developed. For example, Protegen stores over 800 protective antigens experimentally proven valid for vaccine development. VirmugenDB annotated over 200 'virmugens', a term coined by us to represent those virulence factor genes that can be mutated to generate successful live attenuated vaccines. Specific patterns were identified from the genes collected in Protegen and VirmugenDB. VIOLIN also includes Vaxign, the first web-based vaccine candidate prediction program based on reverse vaccinology. VIOLIN collects and analyzes different vaccine components including vaccine adjuvants (Vaxjo) and DNA vaccine plasmids (DNAVaxDB). VIOLIN includes licensed human vaccines (Huvax) and veterinary vaccines (Vevax). The Vaccine Ontology is applied to standardize and integrate various data in VIOLIN. VIOLIN also hosts the Ontology of Vaccine Adverse Events (OVAE) that logically represents adverse events associated with licensed human vaccines.
整合疫苗研究数据库和分析系统（VIOLIN）（http://www.violinet.org）对各种疫苗相关研究数据进行整理、存储、分析和整合。自 2008 年在 NAR 首次发表以来，已经进行了重大更新。从 2007 年底注释的 211 种疫苗开始，VIOLIN 现在包含了超过 3240 种针对 192 种传染病和 8 种非传染性疾病（如癌症和过敏）的疫苗。在 VIOLIN 的保护伞下，开发了>10 个相对独立的程序。例如，Protegen 存储了超过 800 种经实验证明有效的保护性抗原，用于疫苗开发。VirmugenDB 注释了超过 200 个“virmugens”，这是我们创造的一个术语，代表那些可以突变产生成功的减毒活疫苗的毒力因子基因。从 Protegen 和 VirmugenDB 收集的基因中识别出了特定的模式。VIOLIN 还包括 Vaxign，这是第一个基于反向疫苗学的基于网络的疫苗候选物预测程序。VIOLIN 收集和分析了不同的疫苗成分，包括疫苗佐剂（Vaxjo）和 DNA 疫苗质粒（DNAVaxDB）。VIOLIN 包括许可的人类疫苗（Huvax）和兽医疫苗（Vevax）。疫苗本体论用于规范和整合 VIOLIN 中的各种数据。VIOLIN 还托管了疫苗不良事件本体论（OVAE），该本体论逻辑上表示与许可的人类疫苗相关的不良事件。
Zotero 插件