钯催化的不对称分子内 O-芳基化反应：(3,4-二氢-2H-色烯-3-基)甲醇的对映选择性合成。
Pd-catalyzed desymmetric intramolecular O-arylation reaction: enantioselective synthesis of (3,4-dihydro-2H-chromen-3-yl)methanols.
机构信息
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , No. 190 Kaiyuan Avenue, Guangzhou Science Park, Guangzhou, 510530, China, State Key Laboratory of Elemento-organic Chemistry, Nankai Univeristy , No. 94 Weijin Road, Tianjin, 300071, China, and College of Chemistry and Chemical Engineering, Hunan Normal University , No. 36 Lushan Road, Changsha, Hunan, 410081, China.
出版信息
Org Lett. 2013 Dec 6;15(23):6022-5. doi: 10.1021/ol402911y. Epub 2013 Nov 21.
An enantioselective intramolecular O-arylation was achieved through desymmetrization with Pd-catalyzed coupling reactions. The intramolecular asymmetric aryl C-O coupling reactions of 2-(2-haloaryl)propane-1,3-diols led to the enantioselective formation of chiral (3,4-dihydro-2H-chromen-3-yl)methanols in good yields and high enantiomeric selectivity.
通过钯催化偶联反应实现了不对称的分子内 O-芳基化。2-(2-卤代芳基)丙烷-1,3-二醇的分子内不对称芳基 C-O 偶联反应导致手性(3,4-二氢-2H-色烯-3-基)甲醇以良好的收率和高对映选择性形成。
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