Gq-膜雌激素受体信号传导对下丘脑促食欲和抑食欲神经元具有相反的作用。
Gq-mER signaling has opposite effects on hypothalamic orexigenic and anorexigenic neurons.
作者信息
Smith A W, Rønnekleiv O K, Kelly M J
机构信息
Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, OR 97239, USA.
Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, OR 97239, USA; Division of Neuroscience, Oregon National Primate Research Center, Beaverton, OR 97006, USA.
出版信息
Steroids. 2014 Mar;81:31-5. doi: 10.1016/j.steroids.2013.11.007. Epub 2013 Nov 20.
Abstract
Two populations of cells within the hypothalamus exert opposite actions on food intake: proopiomelanocortin (POMC) neurons decrease it, while neuropeptide Y (NPY)/agouti-related peptide (AgRP) neurons increase it. 17β-Estradiol (E2) is a potent anorexigenic hormone that exerts both genomic and non-genomic, rapid actions on these metabolic neurons. This review focuses on the rapid membrane effects of E2 in both POMC and NPY/AgRP neurons and how these combined effects mediate the anorexigenic effects of this steroid.
摘要
下丘脑内的两类细胞群对食物摄入发挥相反作用
促阿片黑素皮质素（POMC）神经元会减少食物摄入，而神经肽Y（NPY）/刺鼠相关肽（AgRP）神经元则会增加食物摄入。17β-雌二醇（E2）是一种强效的厌食激素，对这些代谢神经元具有基因组和非基因组的快速作用。本综述聚焦于E2在POMC和NPY/AgRP神经元中的快速膜效应，以及这些联合效应如何介导这种类固醇的厌食作用。
相似文献
1
Gq-mER signaling has opposite effects on hypothalamic orexigenic and anorexigenic neurons.
Steroids. 2014 Mar;81:31-5. doi: 10.1016/j.steroids.2013.11.007. Epub 2013 Nov 20.
2
The membrane estrogen receptor ligand STX rapidly enhances GABAergic signaling in NPY/AgRP neurons: role in mediating the anorexigenic effects of 17β-estradiol.
Am J Physiol Endocrinol Metab. 2013 Sep 1;305(5):E632-40. doi: 10.1152/ajpendo.00281.2013. Epub 2013 Jul 2.
3
Estradiol Drives the Anorexigenic Activity of Proopiomelanocortin Neurons in Female Mice.
eNeuro. 2018 Oct 10;5(4). doi: 10.1523/ENEURO.0103-18.2018. eCollection 2018 Jul-Aug.
4
Diverse actions of estradiol on anorexigenic and orexigenic hypothalamic arcuate neurons.
Horm Behav. 2018 Aug;104:146-155. doi: 10.1016/j.yhbeh.2018.04.001. Epub 2018 Apr 21.
5
Ghrelin receptors mediate ghrelin-induced excitation of agouti-related protein/neuropeptide Y but not pro-opiomelanocortin neurons.
J Neurochem. 2017 Aug;142(4):512-520. doi: 10.1111/jnc.14080. Epub 2017 Jun 21.
6
Direct and indirect effects of liraglutide on hypothalamic POMC and NPY/AgRP neurons - Implications for energy balance and glucose control.
Mol Metab. 2019 Oct;28:120-134. doi: 10.1016/j.molmet.2019.07.008. Epub 2019 Jul 31.
7
Coordinate regulation of neuropeptide Y and agouti-related peptide gene expression by estrogen depends on the ratio of estrogen receptor (ER) alpha to ERbeta in clonal hypothalamic neurons.
Mol Endocrinol. 2006 Sep;20(9):2080-92. doi: 10.1210/me.2006-0027. Epub 2006 May 4.
8
Comparative Transcriptomic Analyses of Developing Melanocortin Neurons Reveal New Regulators for the Anorexigenic Neuron Identity.
J Neurosci. 2020 Apr 15;40(16):3165-3177. doi: 10.1523/JNEUROSCI.0155-20.2020. Epub 2020 Mar 25.
9
Somato-dendritic localization and signaling by leptin receptors in hypothalamic POMC and AgRP neurons.
PLoS One. 2013 Oct 29;8(10):e77622. doi: 10.1371/journal.pone.0077622. eCollection 2013.
10
Estradiol Protects Neuropeptide Y/Agouti-Related Peptide Neurons against Insulin Resistance in Females.
Neuroendocrinology. 2020;110(1-2):105-118. doi: 10.1159/000501560. Epub 2019 Jun 19.
引用本文的文献
1
Obesity: a gender-view.
J Endocrinol Invest. 2024 Feb;47(2):299-306. doi: 10.1007/s40618-023-02196-z. Epub 2023 Sep 23.
2
Role of estrogen in the regulation of central and peripheral energy homeostasis: from a menopausal perspective.
Ther Adv Endocrinol Metab. 2023 Sep 15;14:20420188231199359. doi: 10.1177/20420188231199359. eCollection 2023.
3
The importance of estradiol for body weight regulation in women.
Front Endocrinol (Lausanne). 2022 Nov 7;13:951186. doi: 10.3389/fendo.2022.951186. eCollection 2022.
4
Hypothalamic Estrogen Signaling and Adipose Tissue Metabolism in Energy Homeostasis.
Front Endocrinol (Lausanne). 2022 Jun 9;13:898139. doi: 10.3389/fendo.2022.898139. eCollection 2022.
5
Estrogenic regulation of reproduction and energy homeostasis by a triumvirate of hypothalamic arcuate neurons.
J Neuroendocrinol. 2022 Jun;34(6):e13145. doi: 10.1111/jne.13145. Epub 2022 May 17.
6
Estrogen Receptor Function: Impact on the Human Endometrium.
Front Endocrinol (Lausanne). 2022 Feb 28;13:827724. doi: 10.3389/fendo.2022.827724. eCollection 2022.
7
Neurodegenerative Disease: Roles for Sex, Hormones, and Oxidative Stress.
Endocrinology. 2021 Nov 1;162(11). doi: 10.1210/endocr/bqab185.
8
Health benefits attributed to 17α-estradiol, a lifespan-extending compound, are mediated through estrogen receptor α.
Elife. 2020 Dec 8;9:e59616. doi: 10.7554/eLife.59616.
9
Membrane and nuclear initiated estrogenic regulation of homeostasis.
Steroids. 2021 Apr;168:108428. doi: 10.1016/j.steroids.2019.108428. Epub 2019 Jun 20.
10
Estradiol Drives the Anorexigenic Activity of Proopiomelanocortin Neurons in Female Mice.
eNeuro. 2018 Oct 10;5(4). doi: 10.1523/ENEURO.0103-18.2018. eCollection 2018 Jul-Aug.
本文引用的文献
1
The membrane estrogen receptor ligand STX rapidly enhances GABAergic signaling in NPY/AgRP neurons: role in mediating the anorexigenic effects of 17β-estradiol.
Am J Physiol Endocrinol Metab. 2013 Sep 1;305(5):E632-40. doi: 10.1152/ajpendo.00281.2013. Epub 2013 Jul 2.
2
Ablation of neurons expressing agouti-related protein, but not melanin concentrating hormone, in leptin-deficient mice restores metabolic functions and fertility.
Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):3155-60. doi: 10.1073/pnas.1120501109. Epub 2012 Jan 9.
3
Defining POMC neurons using transgenic reagents: impact of transient Pomc expression in diverse immature neuronal populations.
Endocrinology. 2012 Mar;153(3):1219-31. doi: 10.1210/en.2011-1665. Epub 2011 Dec 13.
4
Distinct hypothalamic neurons mediate estrogenic effects on energy homeostasis and reproduction.
Cell Metab. 2011 Oct 5;14(4):453-65. doi: 10.1016/j.cmet.2011.08.009.
5
Genetic rescue of nonclassical ERα signaling normalizes energy balance in obese Erα-null mutant mice.
J Clin Invest. 2011 Feb;121(2):604-12. doi: 10.1172/JCI41702. Epub 2011 Jan 18.
6
AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training.
Nat Neurosci. 2011 Mar;14(3):351-5. doi: 10.1038/nn.2739. Epub 2010 Jan 5.
7
Contribution of a membrane estrogen receptor to the estrogenic regulation of body temperature and energy homeostasis.
Endocrinology. 2010 Oct;151(10):4926-37. doi: 10.1210/en.2010-0573. Epub 2010 Aug 4.
8
17 β-estradiol rapidly increases ATP-sensitive potassium channel activity in gonadotropin-releasing hormone neurons [corrected] via a protein kinase signaling pathway.
Endocrinology. 2010 Sep;151(9):4477-84. doi: 10.1210/en.2010-0177. Epub 2010 Jul 21.
9
A thermosensory pathway mediating heat-defense responses.
Proc Natl Acad Sci U S A. 2010 May 11;107(19):8848-53. doi: 10.1073/pnas.0913358107. Epub 2010 Apr 26.
10
Pomc-expressing progenitors give rise to antagonistic neuronal populations in hypothalamic feeding circuits.
Nat Med. 2010 Apr;16(4):403-5. doi: 10.1038/nm.2126. Epub 2010 Mar 28.
Zotero 插件