丙酮酸激酶在脑内颗粒上的结合。
Pyruvate kinase binding to particles in brain.
机构信息
Department of Oral Biology, University of Manitoba, R3E OW3, Winnipeg, Manitoba, Canada.
出版信息
Neurochem Res. 1977 Oct;2(5):461-7. doi: 10.1007/BF00966007.
PMID:24272238
Abstract
Interaction of pyruvate kinase with membrane fractions of rat brain homogenates was shown to be electrostatic. Ionic compounds readily solubilized the enzyme from membranes, and the enzyme was more readily solubilized at high pH versus low pH. Developmental patterns indicated that the particulate and soluble forms of pyruvate kinase increased nearly in synchrony from birth until maturity.
摘要
研究表明，丙酮酸激酶与大鼠脑匀浆的膜部分相互作用是静电的。离子化合物可轻易将酶从膜中溶解出来，且在高 pH 值下酶比在低 pH 值下更容易溶解。发育模式表明，从出生到成熟，丙酮酸激酶的颗粒形式和可溶性形式几乎同步增加。
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