赖氨酸在小鼠脑和其他器官中转化为哌啶、尸胺和哌可酸。
The conversion of lysine into piperidine, cadaverine, and pipecolic acid in the brain and other organs of the mouse.
机构信息
Laboratory of Neuropsychopharmacology Department of Biobehavioral Sciences, University of Connecticut, 06268, Storrs, Connecticut.
出版信息
Neurochem Res. 1977 Dec;2(6):619-37. doi: 10.1007/BF00963776.
The biosynthesis of piperidine, a possible neuromodulator, and its presumed precursors cadaverine and pipecolic acid, has been investigated in the mouse under in vitro conditions. Conversion of lysine into piperidine was observed only in the intestines and is probably caused by the intestinal flora. Formation of cadaverine and pipecolic acid from lysine was observed in the brain, liver, kidney, and large intestine. In addition, pipecolic acid was formed in the heart. The possible contributions of the diet and of the intestinal bacteria to the endogenous pool(s) of piperidine are discussed.
在体外条件下，研究了作为可能的神经调质的哌啶及其假定前体腐胺和哌可酸在小鼠体内的生物合成。仅在肠道中观察到赖氨酸转化为哌啶，这可能是由肠道菌群引起的。在大脑、肝脏、肾脏和大肠中观察到赖氨酸形成腐胺和哌可酸。此外，在心也形成了哌可酸。讨论了饮食和肠道细菌对哌啶内源性池的可能贡献。
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