Plant Research International, Wageningen University and Research Centre, Droevendaalsesteeg 1, 6708 PB Wageningen, The Netherlands.
Plant Developmental Biology, Wageningen University and Research Centre, Droevendaalsesteeg 1, 6708 PB Wageningen, The Netherlands.
Trends Plant Sci. 2014 Mar;19(3):146-57. doi: 10.1016/j.tplants.2013.10.010. Epub 2013 Nov 24.
Members of the AINTEGUMENTA-LIKE (AIL) family of APETALA 2/ETHYLENE RESPONSE FACTOR (AP2/ERF) domain transcription factors are expressed in all dividing tissues in the plant, where they have central roles in developmental processes such as embryogenesis, stem cell niche specification, meristem maintenance, organ positioning, and growth. When overexpressed, AIL proteins induce adventitious growth, including somatic embryogenesis and ectopic organ formation. The Arabidopsis (Arabidopsis thaliana) genome contains eight AIL genes, including AINTEGUMENTA, BABY BOOM, and the PLETHORA genes. Studies on these transcription factors have revealed their intricate relationship with auxin as well as their involvement in an increasing number of gene regulatory networks, in which extensive crosstalk and feedback loops have a major role.
AIL 家族成员属于 APETALA 2/ETHYLENE RESPONSE FACTOR（AP2/ERF）结构域转录因子，在植物所有分裂组织中表达，在胚胎发生、干细胞龛规范、分生组织维持、器官定位和生长等发育过程中发挥核心作用。当过量表达时，AIL 蛋白会诱导不定生长，包括体细胞胚胎发生和异位器官形成。拟南芥（Arabidopsis thaliana）基因组包含 8 个 AIL 基因，包括 AINTEGUMENTA、BABY BOOM 和 PLETHORA 基因。对这些转录因子的研究揭示了它们与生长素的复杂关系，以及它们参与越来越多的基因调控网络，其中广泛的串扰和反馈环起着主要作用。
