用于5-羟色胺转运体（SERT）的碳-11（¹¹C）和氟-18（¹⁸F）正电子发射断层显像（PET）放射性配体

(11) C and (18) F PET radioligands for the serotonin transporter (SERT).

作者信息

Stehouwer Jeffrey S, Goodman Mark M

机构信息

Center for Systems Imaging, Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA, USA.

出版信息

J Labelled Comp Radiopharm. 2013 Mar-Apr;56(3-4):114-9. doi: 10.1002/jlcr.3011.

DOI:10.1002/jlcr.3011

PMID:24285317

Abstract

The serotonin transporter (SERT) has been implicated in a variety of neuropsychiatric disorders including depression, anxiety, and suicide, and is the target of the selective serotonin reuptake inhibitor (SSRI) class of antidepressants. The availability of SERT-specific positron emission tomography (PET) radioligands will allow the SERT to be studied noninvasively in living subjects through PET imaging of the SERT and occupancy studies of SSRIs. Numerous diaryl sulfide and tropane derivatives have been developed and radiolabeled with (11) C or (18) F for imaging the SERT with PET.

摘要

血清素转运体（SERT）与包括抑郁症、焦虑症和自杀在内的多种神经精神疾病有关，并且是选择性5-羟色胺再摄取抑制剂（SSRI）类抗抑郁药的作用靶点。SERT特异性正电子发射断层扫描（PET）放射性配体的可用性，将使得通过对SERT进行PET成像以及对SSRI进行占有率研究，在活体受试者中对SERT进行非侵入性研究成为可能。已经开发出了许多二芳基硫化物和托烷衍生物，并用（11）C或（18）F进行放射性标记，以便用PET对SERT进行成像。