姜黄素通过 Reggie-1/Flotillin-2 促进皮质神经元的突起生长。
Curcumin promotes neurite outgrowth via reggie-1/flotillin-2 in cortical neurons.
机构信息
Department of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, No.12 Mid Wulumuqi Road, Shanghai 200040, PR China; Department of Neurology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, No.110 Ganhe Road, Shanghai 200437, PR China.
Department of Cardiology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, No.110 Ganhe Road, Shanghai 200437, PR China.
出版信息
Neurosci Lett. 2014 Jan 24;559:7-12. doi: 10.1016/j.neulet.2013.11.029. Epub 2013 Nov 25.
Curcumin is well known as an antioxidant and anti-inflammatory agent. In this study, we provided convincing evidence for the function of curcumin in neurite outgrowth of cortical neurons. We discovered that curcumin treatment could promote the number of processes, mean process length, and maximum process length of primary neurons, which were inhibited by reggie-1 siRNAs or extracellular signal-regulated kinase (ERK) 1/2 antagonist. Furthermore, curcumin-induced neurite growth was related to the ERK1/2 phosphorylation, which was blocked by reggie-1 knockdown. Overall, our results implied that curcumin could mediate neurite outgrowth through reggie-1 and ERK1/2 pathway.
姜黄素作为一种抗氧化剂和抗炎剂广为人知。在这项研究中，我们为姜黄素在皮质神经元突起生长中的作用提供了令人信服的证据。我们发现，姜黄素处理可以促进原代神经元的突起数量、平均突起长度和最长突起长度，而这一过程被 reggie-1 siRNA 或细胞外信号调节激酶 (ERK) 1/2 拮抗剂所抑制。此外，姜黄素诱导的突起生长与 ERK1/2 磷酸化有关，而 reggie-1 的敲低可以阻断这一过程。总的来说，我们的结果表明，姜黄素可以通过 reggie-1 和 ERK1/2 通路来介导突起生长。
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