Seo Young Joon, Li Zheng Jun, Choi Dae Kyoung, Sohn Kyung Cheol, Kim Hyeong Rae, Lee Young, Kim Chang Deok, Lee Young Ho, Shi Ge, Lee Jeung Hoon, Im Myung
Department of Dermatology, College of Medicine, Chungnam National University, Daejeon, Korea.
Exp Dermatol. 2014 Jan;23(1):70-2. doi: 10.1111/exd.12291.
Androgens are important hormones that influence sebum production from the sebaceous glands. Human facial skin can be categorized as T- and U-zones, which are areas with high and low levels of sebum secretion, respectively. This study was performed to investigate whether there are topographical differences in androgen receptor (AR) expression related to regional variations in facial sebum secretion. The results of in vivo analysis indicated a statistically significant increase in AR expression in the sebaceous gland T-zones compared with the U-zones. In vitro experiments using human primary sebocytes also yielded similar results, with higher levels of AR protein and mRNA expression in T-zones. The results of this study suggested that differences in androgen susceptibility may be an important factor influencing regional differences in sebum production in human facial skin.
雄激素是影响皮脂腺皮脂分泌的重要激素。人类面部皮肤可分为T区和U区，分别是皮脂分泌水平高和低的区域。本研究旨在调查雄激素受体（AR）表达是否存在与面部皮脂分泌区域差异相关的地形差异。体内分析结果表明，与U区相比，皮脂腺T区的AR表达有统计学意义的增加。使用人原代皮脂细胞的体外实验也得出了类似的结果，T区的AR蛋白和mRNA表达水平更高。本研究结果表明，雄激素敏感性差异可能是影响人类面部皮肤皮脂分泌区域差异的重要因素。
