全身磁共振成像（MRI），包括扩散加权成像，用于淋巴瘤分期：一项前瞻性多中心研究中与CT的比较

Whole-body MRI, including diffusion-weighted imaging, for staging lymphoma: comparison with CT in a prospective multicenter study.

作者信息

Kwee Thomas C, Vermoolen Malou A, Akkerman Erik A, Kersten Marie José, Fijnheer Rob, Ludwig Inge, Beek Frederik J A, van Leeuwen Maarten S, Bierings Marc B, Bruin Marrie C A, Zsíros József, Quarles van Ufford Henriëtte M E, de Klerk John M H, Adam Judit, Stoker Jaap, Uiterwaal Cuno S, Nievelstein Rutger A J

机构信息

Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands.

出版信息

J Magn Reson Imaging. 2014 Jul;40(1):26-36. doi: 10.1002/jmri.24356. Epub 2013 Oct 31.

DOI:10.1002/jmri.24356

PMID:24307538

Abstract

PURPOSE

To compare whole-body magnetic resonance imaging (MRI), including diffusion-weighted imaging (DWI), to computed tomography (CT) for staging newly diagnosed lymphoma.

MATERIALS AND METHODS

In all, 108 patients with newly diagnosed lymphoma prospectively underwent whole-body MRI (T1-weighted and T2-weighted short inversion time inversion recovery [n = 108], and DWI [n = 104]) and CT. Ann Arbor stages were assigned according to whole-body MRI and CT findings. Staging disagreements were resolved using bone marrow biopsy, FDG-PET, and follow-up studies. The results were descriptively analyzed.

RESULTS

Staging results of whole-body MRI without DWI were equal to those of CT in 66.6%, higher in 24.1%, and lower in 9.3%, with correct/incorrect/unresolved higher staging and incorrect/unresolved lower staging relative to CT in 15/7/4 and 9/1 patient(s), respectively. Staging results of whole-body MRI with DWI were equal to those of CT in 65.4%, higher in 27.9%, and lower in 6.7%, with correct/incorrect/unresolved higher staging and incorrect/unresolved lower staging relative to CT in 18/6/5 and 6/1 patient(s), respectively.

CONCLUSION

The results of this study suggest that whole-body MRI staging equals CT staging in the majority of patients with newly diagnosed lymphoma. No advantage of additional DWI was demonstrated. Whole-body MRI can be a good alternative to CT if radiation exposure should be avoided.

摘要

目的

比较全身磁共振成像（MRI），包括扩散加权成像（DWI）与计算机断层扫描（CT）对新诊断淋巴瘤的分期情况。

材料与方法

总共108例新诊断淋巴瘤患者前瞻性地接受了全身MRI检查（T1加权和T2加权短反转时间反转恢复序列[n = 108]，以及DWI[n = 104]）和CT检查。根据全身MRI和CT检查结果确定Ann Arbor分期。分期不一致的情况通过骨髓活检、氟代脱氧葡萄糖正电子发射断层显像（FDG-PET）和随访研究来解决。对结果进行描述性分析。

结果

未进行DWI的全身MRI分期结果与CT分期结果相同的占66.6%，高于CT分期结果的占24.1%，低于CT分期结果的占9.3%，相对于CT，全身MRI正确/错误/未明确的分期较高的分别为15/7/4例，错误/未明确的分期较低的分别为9/1例。进行DWI的全身MRI分期结果与CT分期结果相同的占65.4%，高于CT分期结果的占27.9%，低于CT分期结果的占6.7%，相对于CT，全身MRI正确/错误/未明确的分期较高的分别为18/6/5例，错误/未明确的分期较低的分别为6/1例。