泛素化对MHC II类-肽复合物表达的调控
Regulation of MHC Class II-Peptide Complex Expression by Ubiquitination.
作者信息
Cho Kyung-Jin, Roche Paul A
机构信息
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health , Bethesda, MD , USA.
出版信息
Front Immunol. 2013 Nov 13;4:369. doi: 10.3389/fimmu.2013.00369.
Abstract
MHC class II (MHC-II) molecules are present on antigen presenting cells (APCs) and these molecules function by binding antigenic peptides and presenting these peptides to antigen-specific CD4(+) T cells. APCs continuously generate and degrade MHC-II molecules, and ubiquitination of MHC-II has recently been shown to be a key regulator of MHC-II expression in dendritic cells (DCs). In this mini-review we will examine the mechanism by which the E3 ubiquitin ligase March-I regulates MHC-II expression on APCs and will discuss the functional consequences of altering MHC-II ubiquitination.
摘要
MHC II类（MHC-II）分子存在于抗原呈递细胞（APC）上，这些分子通过结合抗原肽并将这些肽呈递给抗原特异性CD4(+) T细胞发挥作用。APC持续产生和降解MHC-II分子，最近研究表明，MHC-II的泛素化是树突状细胞（DC）中MHC-II表达的关键调节因子。在这篇小型综述中，我们将研究E3泛素连接酶March-I调节APC上MHC-II表达的机制，并讨论改变MHC-II泛素化的功能后果。
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