Gallo I, Nistal F, Fernandez D, Factor S M, Frater R W
Thorac Cardiovasc Surg. 1986 Oct;34(5):310-5. doi: 10.1055/s-2007-1022161.
We compared the morphological findings in 15 young sheep in which standard Hancock-I cardiac bioprostheses (7 animals) and T6-processed Hancock-I (8 animals) were implanted in the tricuspid position. The animals were sacrificed at intervals from 8 to 47 weeks after valve replacement. No valvular infection was detected. Six of the 7 untreated valves and 5 of the 8 T6-processed valves in the tricuspid position showed calcific deposits in the radiographic examination. Roentgenograms from all specimens showed a fairly uneven distribution of the mineralization sites with the commissures being the structure most frequently involved. Calcium in the aortic wall was more frequent in the T6-processed group while right coronary leaflet involvement more frequent in the control group. Histologic evaluation confirmed the above data and showed a fibrotic reaction with granulomatous degeneration of the muscular shelf in all valves. Comparison of linear regression lines of the evolution of tissue calcium content with time showed no statistically significant difference between the 2 groups. Under the conditions of this study, the T6-treatment does not reduce the extent of calcification in the Hancock-I porcine xenograft after implantation in the tricuspid position in young sheep.
我们比较了15只幼羊的形态学结果，其中7只动物在三尖瓣位置植入标准汉考克-I型心脏生物瓣膜，8只动物植入经T6处理的汉考克-I型瓣膜。在瓣膜置换术后8至47周的不同时间点处死这些动物。未检测到瓣膜感染。在放射学检查中，三尖瓣位置的7个未处理瓣膜中的6个以及8个经T6处理瓣膜中的5个显示有钙化沉积。所有标本的X线片显示矿化部位分布相当不均匀，瓣叶联合处是最常受累的结构。主动脉壁钙化在经T6处理的组中更常见，而右冠状动脉瓣叶受累在对照组中更常见。组织学评估证实了上述数据，并显示所有瓣膜均有纤维化反应以及肌性架的肉芽肿性变性。组织钙含量随时间变化的线性回归线比较显示两组之间无统计学显著差异。在本研究条件下，T6处理并不能降低幼羊三尖瓣位置植入汉考克-I型猪异种移植物后的钙化程度。
