人类乳腺癌和甲状腺癌发生发展过程中蛋白酶体类胰凝乳蛋白酶活性的变化。
Changes in proteasome chymotrypsin-like activity during the development of human mammary and thyroid carcinomas.
作者信息
Shashova E E, Astakhova T M, Plekhanova A S, Bogomyagkova Yu V, Lyupina Yu V, Sumedi I R, Slonimskaya E M, Erokhov P A, Abramova E B, Rodoman G V, Kuznetsov N A, Kondakova I V, Sharova N P, Choinzonov E L
机构信息
Research Cancer Institute, Siberian Division of the Russian Academy of Medical Sciences, Tomsk; N. K. Koltsov Institute of Developmental Biology, the Russian Academy of Sciences; N. I. Pirogov Russian National Research Medical University, the Ministry of Health and Social Development of Russia, Moscow, Russia.
出版信息
Bull Exp Biol Med. 2013 Dec;156(2):242-4. doi: 10.1007/s10517-013-2321-z.
Changes in the proteasome chymotrypsin-like activity in mammary and thyroid carcinomas in comparison with the adjacent tissue were studied at stages T(1-4)N(0-3)M(0) and T(2-3)N(0-1)M(0), respectively. The activities changed in a wave-like manner over the course of mammary carcinoma growth in cases with and without metastases. The minimum increment of the activity in the tumor was recorded during the T(2)N(0) stage in the absence of local metastases. The increment of the activity reached the peak in N(1) tumors of the same size with metastases. The activities in the tumor and adjacent tissues virtually did not differ during the T(3-4)N(1-3) stages. The time course of proteasome activity changes in thyroid tumors of the studied stages was similar to that in mammary carcinoma. The results can be used for development of methods for evaluating the aggressiveness of mammary and thyroid tumors.
分别在T(1 - 4)N(0 - 3)M(0)期和T(2 - 3)N(0 - 1)M(0)期研究了乳腺癌和甲状腺癌中蛋白酶体类胰凝乳蛋白酶活性相对于邻近组织的变化。在有转移和无转移的情况下，蛋白酶体类胰凝乳蛋白酶活性在乳腺癌生长过程中呈波浪状变化。在无局部转移的T(2)N(0)期，肿瘤中该活性的增加最小。在大小相同但有转移的N(1)期肿瘤中，该活性的增加达到峰值。在T(3 - 4)N(1 - 3)期，肿瘤组织和邻近组织中的活性实际上没有差异。所研究阶段的甲状腺肿瘤中蛋白酶体活性变化的时间进程与乳腺癌相似。这些结果可用于开发评估乳腺和甲状腺肿瘤侵袭性的方法。
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