Telen M J, Shehata H, Haynes B F
Hum Immunol. 1986 Nov;17(3):311-24. doi: 10.1016/0198-8859(86)90283-1.
Study of human T lymphocyte differentiation antigens with monoclonal antibodies has led to the identification of two antigens shared by erythrocytes and leukocytes. The protein (p80) defined by A1G3 antibody has previously been shown to be acquired during human intrathymic T-cell maturation. The antigen defined by A3D8 antibody has been demonstrated also to reside on an 80 kd protein; expression of the A3D8 antigen on erythrocytes and a subset of leukocytes is regulated by the rare In(Lu) gene. In this study, we demonstrate that the antigens defined by the A1G3 and A3D8 antibodies reside on the same protein and represent closely related but nonidentical epitopes on the p80 molecule. Expression of the A1G3 antigen on erythrocytes and a subset of leukocytes is also down-regulated by the In(Lu) gene. The possible role of the In(Lu) gene in thymocyte differentiation is discussed.
用单克隆抗体对人类T淋巴细胞分化抗原进行研究，已鉴定出两种红细胞和白细胞共有的抗原。先前已证明，由A1G3抗体定义的蛋白质（p80）是在人类胸腺内T细胞成熟过程中获得的。由A3D8抗体定义的抗原也已证明存在于一种80kd的蛋白质上；红细胞和一部分白细胞上A3D8抗原的表达受罕见的In（Lu）基因调控。在本研究中，我们证明由A1G3和A3D8抗体定义的抗原存在于同一蛋白质上，并且代表p80分子上密切相关但不相同的表位。红细胞和一部分白细胞上A1G3抗原的表达也受In（Lu）基因下调。本文讨论了In（Lu）基因在胸腺细胞分化中的可能作用。
