Nihon Medi-Physics Co. Ltd., 3-4-10 Shinsuna, Koto-Ku, Tokyo 136-0075, Japan; Department of Preventive Medicine and Health, Welfare and Medical Policy, Graduate School of Human Sciences, Waseda University, Saitama, 2-579-15 Mikajima, Tokorozawa, Saitama 359-1192, Japan.
Department of Preventive Medicine and Health, Welfare and Medical Policy, Graduate School of Human Sciences, Waseda University, Saitama, 2-579-15 Mikajima, Tokorozawa, Saitama 359-1192, Japan.
Int J Psychophysiol. 2014 Feb;91(2):67-72. doi: 10.1016/j.ijpsycho.2013.12.001. Epub 2013 Dec 7.
Several authors have reviewed the effects of psychological stress on lymphocyte activity. However the effect of psychological stress on neutrophil functions has not been reviewed. The present meta-analysis summarizes evidence of the effects of psychological stress on neutrophil phagocytosis and bactericidal activity collated from a MEDLINE search of the English literature. We searched the database to identify the relevant studies through April 30, 2013. Eleven studies met our inclusion criteria and we divided them into those addressing transient acute stress (3 studies, n=74), academic examinations (4 studies n=101) and chronic stress/life events (4 studies, n=193). We performed a meta-analysis of the data and calculated total standardized mean differences (SMD) to evaluate the effects of chronic stress. Transient acute stressors might both enhance and decrease these neutrophil functions. Academic examinations tended to elevate neutrophil functions. On the other hand, the total SMDs of neutrophil phagocytosis and bactericidal activity altered by chronic stress/life events were -0.589 (95% CI: -0.908 to -0.270, p<0.05) and -0.547 (95% CI: -0.845 to -0.248, p<0.05), respectively, indicating suppressive effects on these neutrophil functions. Further systematic review of more pooled studies is warranted to confirm that academic examinations might enhance, whereas chronic stress/life events might suppress these neutrophil functions.
几位作者已经回顾了心理压力对淋巴细胞活性的影响。然而，心理压力对中性粒细胞功能的影响尚未得到综述。本荟萃分析总结了从 MEDLINE 搜索英文文献中收集到的关于心理压力对中性粒细胞吞噬和杀菌活性影响的证据。我们搜索了数据库，以确定通过 2013 年 4 月 30 日确定的相关研究。有 11 项研究符合我们的纳入标准，我们将它们分为研究短暂急性应激（3 项研究，n=74）、学术考试（4 项研究，n=101）和慢性应激/生活事件（4 项研究，n=193）。我们对数据进行了荟萃分析，并计算了总标准化均数差（SMD）来评估慢性应激的影响。短暂的急性应激源可能增强和降低这些中性粒细胞功能。学术考试往往会提高中性粒细胞的功能。另一方面，慢性应激/生活事件改变的中性粒细胞吞噬和杀菌活性的总 SMD 分别为-0.589（95%置信区间：-0.908 至-0.270，p<0.05）和-0.547（95%置信区间：-0.845 至-0.248，p<0.05），表明对这些中性粒细胞功能具有抑制作用。需要进一步系统地审查更多的汇总研究，以确认学术考试可能增强，而慢性应激/生活事件可能抑制这些中性粒细胞功能。
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