启东汉族人群中人类白细胞抗原I类多态性与乙型肝炎表面抗原自然清除的关联
Association of human leukocyte antigen class I polymorphism with spontaneous clearance of hepatitis B surface antigen in Qidong Han population.
作者信息
Miao Fengqin, Sun Hang, Pan Ning, Xu Jinhuan, Qiu Jie, Shen Yuqing, Xie Wei, Zhang Jianqiong
机构信息
Medical School, Ministry of Education, Southeast University, Nanjing, Jiangsu 210009, China ; Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, Southeast University, Nanjing, Jiangsu 210096, China.
出版信息
Clin Dev Immunol. 2013;2013:145725. doi: 10.1155/2013/145725. Epub 2013 Nov 13.
AIM
To investigate whether HLA class I polymorphisms could influence the clearance of hepatitis B surface antigen (HBsAg) in Qidong Han population.
METHODS
We genotyped HLA-A, -B, and -C loci of 448 individuals with HBV persistent infection and 140 persons with spontaneous clearance of HBsAg by polymerase chain reaction with sequencing based typing (PCR/SBT). All the individuals were unrelated males enrolled from Qidong Han population and were followed up for 10 years.
RESULTS
The frequency of HLA-A∗33:03:01G was increased in persistent HBV infection group (P value is 0.028), while frequency of HLA-B∗13:01:01G was increased in HBsAg clearance group (P value is 0.0004).
CONCLUSION
These findings suggested that the host HLA class I polymorphism is an important factor in determining the outcomes of HBV infection.
目的
研究人类白细胞抗原I类基因多态性是否会影响启东汉族人群中乙型肝炎表面抗原（HBsAg）的清除。
方法
我们采用基于测序分型的聚合酶链反应（PCR/SBT）对448例HBV持续感染个体和140例自发清除HBsAg的个体进行了HLA - A、- B和 - C基因座的基因分型。所有个体均为来自启东汉族人群的无关男性，并进行了10年的随访。
结果
持续性HBV感染组中HLA - A∗33:03:01G的频率增加（P值为0.028），而HBsAg清除组中HLA - B∗13:01:01G的频率增加（P值为0.0004）。
结论
这些发现表明宿主HLA I类基因多态性是决定HBV感染结局的重要因素。
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