Cui Tao, Ren Yan, Ma Hong, Liu Song-Fang, Zhang Xiang-Xun, Yu Hong-ling
Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu 610041, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2013 Sep;44(5):774-8.
To study the changes of plasma glucagon-like peptide-1 (GLP-1), serum peptide-YY (PYY) and Ghrelin and their secretion functions in patients with newly diagnosed type 2 diabetes mellitus (T2DM).
A total of 102 subjects were enrolled, including 32 normal-glucose-tolerance controls (NGT) and 70 patients with newly diagnosed T2DM. Height, body mass, waist circumference (WC) and hip circumference were measured. The plasma lipids and 0 h, 1/2 h, 2 h plasma glucose, insulin (INS), GLP-1, serum PYY and Ghrelin in a standard meal test in each subject were detected, and body mass index (BMI), homeostasis model assessment of insulin resistance (HOMA-IR), insulin sensitivity index (ISI), homeostasis model assessment of beta cell function (HOMA-B) and early insulin secretion function index (DeltaI30/DeltaG30) were calculated. All these variables were compared between the two groups.
Compared with those in NGT group, the WC, fasting plasma glucose (FPG), postprandial plasma glucose (2 h-PG), triglyceride (TG), HOMA-IR were significantly higher (P 0.05), while INS(30), HOMA-B, ISI, DeltaI30/DeltaG30 were significantly lower in T2DM group (P<0. 05). In addition, in T2DM group, 0 h, 1/2 h, 2 h plasma GLP-1 and serum PYY and the area under the curve (AUC) of GLP-1 (GLP-lAuc ) and PYY (PYYAc) in standard meal test were significantly lower (P<0. 05), but the serum Ghrelin and GhrelinA, were significantly higher (P<0. 05). Meanwhile, the secretory peak of GLP-1 and PYY after standard meal in T2DM patients all disappeared. In T2DM group, PYYAUC and TG were negatively correlated (P<0.05), the fasting serum Ghrelin level was negatively associated with total cholesterol (TC), and GhrelinAuc was positively associated with HOMA-B, but negatively with the low-density lipoprotein cholesterol (LDL-C) and FPG (P(<0. 05).
Patients with newly diagnosed T2DM have decreased fasting and postprandial GLP-1 and PYY levels, along with changes of their secretion mode and increased levels of Ghrelin.
研究新诊断2型糖尿病（T2DM）患者血浆胰高血糖素样肽-1（GLP-1）、血清肽YY（PYY）和胃饥饿素的变化及其分泌功能。
共纳入102名受试者，包括32名糖耐量正常对照者（NGT）和70名新诊断的T2DM患者。测量身高、体重、腰围（WC）和臀围。检测每位受试者标准餐试验中的血脂、0小时、半小时、2小时血浆葡萄糖、胰岛素（INS）、GLP-1、血清PYY和胃饥饿素，并计算体重指数（BMI）、胰岛素抵抗稳态模型评估（HOMA-IR）、胰岛素敏感指数（ISI）、β细胞功能稳态模型评估（HOMA-B）和早期胰岛素分泌功能指数（DeltaI30/DeltaG30）。比较两组间所有这些变量。
与NGT组相比，T2DM组的WC、空腹血糖（FPG）、餐后血糖（2小时-PG）、甘油三酯（TG）、HOMA-IR显著更高（P<0.05），而INS（30）、HOMA-B、ISI、DeltaI30/DeltaG30显著更低（P<0.05）。此外，在T2DM组中，标准餐试验中0小时、半小时、2小时血浆GLP-1和血清PYY以及GLP-1曲线下面积（GLP-1AUC）和PYY曲线下面积（PYYAUC）显著更低（P<0.05），但血清胃饥饿素和胃饥饿素曲线下面积（GhrelinAUC）显著更高（P<0.05）。同时，T2DM患者标准餐后GLP-1和PYY的分泌高峰均消失。在T2DM组中，PYYAUC与TG呈负相关（P<0.05），空腹血清胃饥饿素水平与总胆固醇（TC）呈负相关，GhrelinAUC与HOMA-B呈正相关，但与低密度脂蛋白胆固醇（LDL-C）和FPG呈负相关（P<0.05）。
新诊断的T2DM患者空腹和餐后GLP-1及PYY水平降低，其分泌模式改变，胃饥饿素水平升高。
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