Mocarzel Carolina Carvalho, de Sá Renato Augusto Moreira, Velarde Luis Guillermo Coca, Peixoto-Filho Fernando Maia, Ville Yves
Grupo Perinatal, Rio de Janeiro, Brazil.
Department of Obstetrics, Hospital Servidores do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.
Twin Res Hum Genet. 2014 Feb;17(1):45-50. doi: 10.1017/thg.2013.82. Epub 2013 Dec 13.
The aim of this study was to assess fetal urinary production rates (FUPR) in twin gestations using 3D ultrasonography with VOCAL® (virtual organ computer-aided analysis) and to develop a curve of normal values for the target population.
A cross-sectional study was performed in 30 normal twin pregnancies with gestational ages ranging from 20 to 34 weeks. FUPR was measured using a three-dimensional ultrasound (3D US) virtual organ computer-aided analysis (VOCAL) system. FUPR (ml/hour) was calculated during the filling phase using the equation UPR = (VFB(2) - VFB(1))/time. The values for UPR were plotted as a function of fetal biometry (biparietal diameter) to generate a nomogram.
A total of 41 normal twin fetuses with gestational ages between 20 and 34 weeks were investigated. Eleven were excluded because of inadequate bladder contour image quality and/or the observation of micturition in one or both fetuses. Linear regression analysis of FUPR as a function of biparietal diameter (BPD) shows the normal range for UPR by fetal biometry and is expressed by the following equation: Ln(UPR) = -5.0121 + 0.0548 BPD (R(2) 0.3386, p value <.001). There was no statistically significant difference when the UPR was stratified by chorionicity.
The use of biometric parameters to predict fetal FUPR seems to be useful. In twin pregnancies, BPD is the variable that is most closely related to FUPR. For each 1 mm increase in BPD, there is a 5% increase in FUPR. Chorionicity did not affect FUPR.
本研究旨在使用带有VOCAL®（虚拟器官计算机辅助分析）的三维超声评估双胎妊娠中的胎儿尿液生成率（FUPR），并为目标人群绘制正常数值曲线。
对30例孕龄在20至34周的正常双胎妊娠进行横断面研究。使用三维超声（3D US）虚拟器官计算机辅助分析（VOCAL）系统测量FUPR。在充盈期使用公式UPR = (VFB(2) - VFB(1))/时间计算FUPR（毫升/小时）。将UPR值绘制为胎儿生物测量（双顶径）的函数以生成列线图。
共研究了41例孕龄在20至34周的正常双胎胎儿。11例因膀胱轮廓图像质量不佳和/或观察到一个或两个胎儿排尿而被排除。FUPR作为双顶径（BPD）函数的线性回归分析显示了根据胎儿生物测量得出的UPR正常范围，由以下公式表示：Ln(UPR) = -5.0121 + 0.0548 BPD（R(2) 0.3386，p值<.001）。按绒毛膜性分层时，UPR无统计学显著差异。
使用生物测量参数预测胎儿FUPR似乎是有用的。在双胎妊娠中，BPD是与FUPR最密切相关的变量。BPD每增加1毫米，FUPR增加5%。绒毛膜性不影响FUPR。
