化脓链球菌逃避自噬作用。
Streptococcus pyogenes escapes from autophagy.
机构信息
Section of Bacterial Pathogenesis, Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.
出版信息
Cell Host Microbe. 2013 Dec 11;14(6):604-6. doi: 10.1016/j.chom.2013.11.012.
PMID:24331458
Abstract
Autophagy is important for innate defense against intracellular bacteria, such as Group A Streptococcus (GAS). In this issue of Cell Host & Microbe, Barnett et al. (2013) demonstrate that the globally disseminated serotype M1T1 clone of GAS can evade autophagy via streptococcal cysteine protease SpeB-mediated degradation of ubiquitin-LC3 adaptor proteins.
摘要
自噬对于先天防御细胞内细菌（如 A 组链球菌（GAS））非常重要。在本期《细胞宿主与微生物》中，Barnett 等人（2013 年）证明，全球传播的 GAS M1T1 血清型克隆可以通过链球菌半胱氨酸蛋白酶 SpeB 介导的泛素 LC3 衔接蛋白的降解来逃避自噬。
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