Schiodt Morten, Reibel Jesper, Oturai Peter, Kofod Thomas
Consultant Oral and Maxillofacial Surgeon, Department of Oral & Maxillofacial Surgery, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark.
Professor, Section of Oral Medicine, Clinical Oral Physiology, Oral Pathology and Anatomy, Department of Odontology, University of Copenhagen, Copenhagen, Denmark.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2014 Feb;117(2):204-13. doi: 10.1016/j.oooo.2013.10.010. Epub 2013 Nov 15.
Nonexposed osteonecrosis of the jaws (NE-ONJ) does not fit into the current definition of osteonecrosis, which requires exposed bone. A modification of the classification of bisphosphonate-induced osteonecrosis of the jaws (ONJ) is proposed. This study aimed to test proposed criteria for NE-ONJ and compare NE-ONJ with exposed ONJ (E-ONJ) in a retrospective analysis.
In 102 patients with E-ONJ diagnosed according to Ruggiero et al. (2006, 2009), criteria for NE-ONJ were developed. Subgroups of NE-ONJ and E-ONJ were tested against each other using nonparametric and parametric statistics.
Among 102 patients with ONJ, 14 had NE-ONJ and 88 had E-ONJ. NE-ONJ and E-ONJ were similar in all important data (P > .05) except bone exposure.
NE-ONJ belongs to the same disease condition as E-ONJ. NE-ONJ may be otherwise classified as ONJ stage 1, 2, or 3 and is different from ONJ stage 0. We propose to include the criteria for NE-ONJ into the classification.
颌骨非暴露性骨坏死（NE-ONJ）不符合目前骨坏死的定义，该定义要求有暴露的骨组织。本文提出了双膦酸盐诱导的颌骨骨坏死（ONJ）分类的一种修改方法。本研究旨在通过回顾性分析来检验NE-ONJ的拟定标准，并将NE-ONJ与暴露性ONJ（E-ONJ）进行比较。
在102例根据鲁杰罗等人（2006年、2009年）诊断为E-ONJ的患者中，制定了NE-ONJ的标准。使用非参数和参数统计方法对NE-ONJ和E-ONJ亚组进行相互检验。
在102例ONJ患者中，14例为NE-ONJ，88例为E-ONJ。除骨暴露外，NE-ONJ和E-ONJ在所有重要数据方面均相似（P>.05）。
NE-ONJ与E-ONJ属于同一疾病状态。NE-ONJ可另行分类为ONJ 1期、2期或3期，与ONJ 0期不同。我们建议将NE-ONJ的标准纳入分类中。
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