合成具有潜在抗癌活性的新型青蒿素二聚体系列，涉及 Sonogashira 交叉偶联反应。
Synthesis of a novel series of artemisinin dimers with potent anticancer activity involving Sonogashira cross-coupling reaction.
机构信息
Natural Products Chemistry Division, CSIR-North-East Institute of Science & Technology, Jorhat 785006, Assam, India.
Pharmacology Division, Indian Institute of Integrative Medicine, Jammu 180001, India.
出版信息
Bioorg Med Chem Lett. 2014 Jan 1;24(1):237-9. doi: 10.1016/j.bmcl.2013.11.032. Epub 2013 Nov 23.
PMID:24332623
Abstract
A series of C-10 acetal artemisinin dimers were synthesized using Sonogashira cross-coupling reaction. All these novel semisynthetic artemisinin dimers exhibited excellent growth inhibitory activity against Lung A-549 human cancer cell line.
摘要
采用 Sonogashira 交叉偶联反应合成了一系列 C-10 缩醛青蒿素二聚体。所有这些新型半合成青蒿素二聚体对 Lung A-549 人癌细胞系均表现出优异的生长抑制活性。
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