Center of Transplant Surgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan 421001, PR China; Department of General Surgery, the First Affiliated Hospital, South China University, Hengyang, 421001 Hunan, PR China.
Department of Anesthesiology, The Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, PR China.
Biomed Pharmacother. 2014 Feb;68(1):25-30. doi: 10.1016/j.biopha.2013.11.004. Epub 2013 Nov 26.
Pancreatic cancer is one of the most common types of cancers in the whole world with a poor prognosis. Finding out how the cancer form and develop is the most important way to cure this cancer. miRNAs, 21-22 nucleotides regulatory small non-coding RNAs, have been found to be critical involved in the growth of pancreatic cancer. In this study, we found that miR-92a was up regulated in three kinds of human pancreatic cancer cell lines. There is a correlation between miR-92a and malignant degree of human pancreatic cancer cell lines. Then we found that miR-92a was essential for promoting cell proliferation in human pancreatic cancer. Inhibition of the function of miR-92a repressed the proliferation of pancreatic cancer cells. Further, we found that miR-92a enhanced the activation of JNK signalling pathway by directly targeting the JNK signalling inhibitor DUSP10. DUSP10 is responsible for miR-92a induced JNK signalling and cell proliferation. Altogether, our study showed a miR-92a/DUSP10/JNK signalling pathway that plays an important role in regulating the proliferation of pancreatic cancer cells.
胰腺癌是全世界最常见的癌症类型之一，预后较差。了解癌症的形成和发展是治愈这种癌症的最重要途径。miRNAs 是 21-22 个核苷酸的调节性小非编码 RNA，已被发现与胰腺癌的生长密切相关。在本研究中，我们发现 miR-92a 在三种人类胰腺癌细胞系中上调。miR-92a 与人类胰腺癌细胞系的恶性程度之间存在相关性。然后，我们发现 miR-92a 对促进人类胰腺癌细胞增殖是必需的。抑制 miR-92a 的功能会抑制胰腺癌细胞的增殖。此外，我们发现 miR-92a 通过直接靶向 JNK 信号通路抑制剂 DUSP10 增强 JNK 信号通路的激活。DUSP10 负责 miR-92a 诱导的 JNK 信号和细胞增殖。总之，我们的研究表明，miR-92a/DUSP10/JNK 信号通路在调节胰腺癌细胞增殖中起着重要作用。
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