Program in Neuroscience, Department of Psychology, Bates College, 4 Andrews Road, Lewiston, ME 04240, USA.
Neurosci Lett. 2014 Jan 24;559:169-73. doi: 10.1016/j.neulet.2013.12.004. Epub 2013 Dec 12.
Circulating levels of brain-derived neurotrophic factor (BDNF) are known to be affected by aerobic exercise. As the previous research focus in humans has been to examine peripheral BDNF levels through blood, serum, and platelet assay, the present study investigated the association between basal urinary BDNF concentration and indices of aerobic fitness in a sample of young adults (n=52). Aerobic fitness was evaluated with self-report of exercise habits and heart rate (HR) assessment during a sub-maximal Step Test. BDNF concentration was determined by enzyme-linked immunosorbent assay and adjusted for creatinine. Results indicated that the basal BDNFlog/creatinine ratio was positively associated with greater frequency of exercise and, during aerobic challenge, a quicker rise in HR upon exercise, lower peak HR during exercise, and lower HR during the recovery period, each indicative of enhanced fitness. These results highlight the utility of urine capture as a non-invasive technique to assess for exercise-mediated changes in peripheral BDNF.
已知循环中的脑源性神经营养因子（BDNF）水平受有氧运动的影响。由于先前的人类研究重点是通过血液、血清和血小板检测来检查外周 BDNF 水平，因此本研究在年轻成年人样本中调查了基础尿 BDNF 浓度与有氧健身指数之间的关系（n=52）。通过自我报告的运动习惯和亚最大强度台阶测试期间的心率（HR）评估来评估有氧健身能力。BDNF 浓度通过酶联免疫吸附测定法测定，并根据肌酐进行调整。结果表明，基础 BDNFlog/肌酐比值与更高的运动频率呈正相关，并且在有氧运动期间，HR 在运动时更快上升，运动时的峰值 HR 更低，以及恢复期的 HR 更低，这些都表明了更好的适应性。这些结果突出了尿液采集作为一种非侵入性技术来评估外周 BDNF 运动介导变化的效用。
