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德国颅内动脉瘤性蛛网膜下腔出血的治疗:2005-2009 年全国性分析。

Treatment of aneurysmal subarachnoid haemorrhage in Germany: a nationwide analysis of the years 2005-2009.

机构信息

Institut für Klinische Epidemiologie, Medizinische Fakultät, Halle, Germany.

出版信息

Neuroepidemiology. 2014;42(2):90-7. doi: 10.1159/000355843. Epub 2013 Dec 3.

DOI:10.1159/000355843
PMID:24334973
Abstract

BACKGROUND

The aim of this study was to provide population-based nationwide rates of the different treatment modalities of aneurysmal subarachnoid haemorrhage (aSAH).

METHODS

German Diagnosis-Related Group data of the years 2005-2009 were used to calculate hospitalisation rates for intracranial aneurysm with aSAH. This study includes over 83 million hospitalisations.

RESULTS

We identified 15,768 hospitalisations with a diagnosis of aSAH. Throughout the observation period, the age-standardised rate for both sexes increased by 69% (95% confidence interval, CI 54-84) for coiling and 13% (95% CI 4-23) for clipping. The estimated annual percent change in the overall hospitalisation rate was 7.4% (95% CI 5.2-9.6). Age-standardised hospitalisation rates varied considerably by region. The estimated hospitalisation rate ratio of overall hospitalisation rates (East/West) was 0.86 (95% CI 0.80-0.91) for males and 0.81 (95% CI 0.77-0.85) for females. After adjustment for age and co-morbidity, the hazard ratio (HR) for in-hospital mortality was higher for coiling than clipping (HR = 1.12, 95% CI 1.01-1.23). Patients who received coiling or clipping had ventricular shunt placement in 5.0 (n = 819) and 6.1% (n = 998), respectively. The estimated length of stay was 3.3 days (95% CI 2.56-4.05) shorter for coiling than clipping.

CONCLUSIONS

We provide for the first time nationwide, representative hospitalisation rates for the treatment of aSAH. Our results indicate a change in the practice pattern for Germany during the observation period. We observed a gradual increase in overall hospitalisation rates for aSAH.

摘要

背景

本研究旨在提供基于人群的、全国范围内不同治疗方式治疗蛛网膜下腔出血(aSAH)的发病率。

方法

本研究使用了 2005-2009 年德国疾病诊断相关分组数据,以计算颅内动脉瘤伴 aSAH 的住院率。本研究共纳入了超过 8300 万例住院患者。

结果

我们共发现了 15768 例蛛网膜下腔出血的诊断住院患者。在整个观察期间,男性和女性的血管内介入治疗(coiling)和开颅夹闭手术(clipping)的年龄标准化发病率分别增加了 69%(95%置信区间:54-84)和 13%(95%置信区间:4-23)。总体住院率的年估计百分比变化为 7.4%(95%置信区间:5.2-9.6)。各地区的年龄标准化住院率差异较大。东德/西德的总体住院率(ratio)的估计比值为 0.86(95%置信区间:0.80-0.91),男性为 0.81(95%置信区间:0.77-0.85),女性为 0.81(95%置信区间:0.77-0.85)。在调整年龄和合并症后,血管内介入治疗的院内死亡率的风险比(HR)高于开颅夹闭手术(HR=1.12,95%置信区间:1.01-1.23)。接受血管内介入治疗和开颅夹闭手术的患者中分别有 5.0%(n=819)和 6.1%(n=998)放置了脑室引流管。血管内介入治疗的估计住院时间比开颅夹闭手术短 3.3 天(95%置信区间:2.56-4.05)。

结论

我们首次提供了全国范围内蛛网膜下腔出血治疗的代表性住院率。我们的结果表明,在观察期间德国的治疗模式发生了变化。我们观察到蛛网膜下腔出血的总住院率逐渐增加。

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