肺炎球菌结合疫苗接种方案的系统评价方法。
Methods for a systematic review of pneumococcal conjugate vaccine dosing schedules.
机构信息
From the *Respiratory Diseases Branch, Division of Bacterial Diseases, National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA; †International Vaccine Access Center, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; ‡Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, GA; §Westat Inc., Rockville, MD; ¶Biostatistics Consulting, Chicago, IL; and ‖Institute of Child Health, University College London, London, United Kingdom.
出版信息
Pediatr Infect Dis J. 2014 Jan;33 Suppl 2(Suppl 2 Optimum Dosing of Pneumococcal Conjugate Vaccine For Infants 0 A Landscape Analysis of Evidence Supportin g Different Schedules):S182-7. doi: 10.1097/INF.0000000000000085.
BACKGROUND
Streptococcus pneumoniae causes a considerable amount of morbidity and mortality in children <5. However, pneumococcal conjugate vaccines (PCVs) can prevent much of this burden. Until recently, PCVs were mostly available only in developed countries using a variety of dosing schedules. As more lower income countries make decisions to introduce PCV into their national immunization programs, an optimal schedule with which to administer PCV has become a key policy question.
METHODS
We performed a systematic review of English literature published from 1994 to 2010 on the effects of PCV dosing schedules on immunogenicity, nasopharyngeal carriage, invasive pneumococcal disease and pneumonia. Data were independently double abstracted and cleaned for analysis. Descriptive analyses were performed.
RESULTS
We identified 12,980 citations from the literature search (12,976) and secondary means (44). Double review of titles and abstracts yielded 769 articles that underwent full data abstraction. Of these, 350 were further analyzed and are presented in separate reports in this supplement.
CONCLUSIONS
This article presents the methods utilized in our systematic review. Because of the heterogenity of the study methods of the reports identified by this review, we did not conduct formal meta-analyses. However, these methods allow us to present a full landscape of the literature on PCV dosing schedules.
背景
肺炎链球菌可导致大量<5 岁儿童发病和死亡。然而，肺炎球菌结合疫苗（PCV）可预防很大一部分负担。直到最近，PCV 主要仅在发达国家使用多种剂量方案获得。随着越来越多的低收入国家决定将 PCV 纳入其国家免疫规划，管理 PCV 的最佳方案已成为一个关键政策问题。
方法
我们对 1994 年至 2010 年发表的关于 PCV 剂量方案对免疫原性、鼻咽携带、侵袭性肺炎球菌病和肺炎影响的英文文献进行了系统评价。数据由独立的双人双次摘要和清理进行分析。进行描述性分析。
结果
我们从文献检索（12,976）和二级来源（44）中识别出 12,980 条引文。对标题和摘要进行双人双重审查后，有 769 篇文章进行了全面数据提取。其中，有 350 篇文章进一步进行了分析，并在本增刊中的单独报告中呈现。
结论
本文介绍了我们系统评价中使用的方法。由于本综述确定的报告的研究方法存在异质性，我们未进行正式的荟萃分析。但是，这些方法使我们能够全面了解关于 PCV 剂量方案的文献。
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