[低浓度河豚毒素对大鼠三叉神经节神经元离子电流的影响]
[Effect of tetrodotoxin in low concentrations on the ion currents of trigeminal ganglion neurons in the rat].
作者信息
Pidoplichko V I
出版信息
Neirofiziologiia. 1986;18(6):723-9.
Isolated neurons from trigeminal ganglia of one-month-old rats were studied under conditions of intracellular perfusion and voltage clamp. Increase of the inward current amplitude and deceleration of current decay due to the action of low external concentrations of tetrodotoxin (10(-12)-10(-10) M) were observed in a number of the cells tested. Such changes were absent in chloride-free extracellular solution. The existence of a transient potential-dependent current carried by chloride anions through tetrodotoxin-sensitive chloride channels in the membrane of trigeminal ganglion neurons is postulated.
对1月龄大鼠三叉神经节的分离神经元进行了细胞内灌注和电压钳条件下的研究。在许多受试细胞中观察到，由于低细胞外浓度的河豚毒素（10^(-12)-10^(-10)M）的作用，内向电流幅度增加且电流衰减减慢。在无氯化物的细胞外溶液中未出现这种变化。推测三叉神经节神经元膜中存在由氯离子通过河豚毒素敏感的氯通道携带的瞬时电位依赖性电流。
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