Consultant in Medical Oncology, Imperial Hospitals NHS Trust, Charing Cross Hospital, London W6 8RF, UK.
QJM. 2014 Apr;107(4):277-82. doi: 10.1093/qjmed/hct244. Epub 2013 Dec 11.
Malignant spinal cord compression (mSCC) is one of the most serious complications of cancer. Recent NICE guidance has aimed to improve patient pathways and outcomes for patients with mSCC. We have examined the current presentations, management and outcomes for patients with mSCC in West London following the implementation of the NICE guidance.
The electronic records and clinical notes were reviewed for all patients assessed for confirmed or potential mSCC at Charing Cross Hospital in 2012. Details on the number of referrals, the proportion with confirmed mSCC, the cancer diagnosis, treatment and outcome were analysed.
191 patients were reviewed with 127 (66%) cases of confirmed mSCC. The commonest tumour types were prostate cancer (26 cases), lung cancer (26), breast cancer (21) and kidney cancer (15). 21% of the patients had no previous cancer diagnosis; mSCC was their presenting diagnostic event. Radiotherapy was the predominant management, 24% of the patients had first line surgical treatment. At presentation 62% of patients were either chair or bed bound. Treatment brought important mobility benefits to all patients groups with 20% of the initially chair or bed bound patients leaving the hospital with independent mobility.
Enhanced patients pathways with ease of access, rapid assessment and prompt treatment can improve outcomes. Despite these pathways many patients still present with gross motor impairment and over 20% have no previous diagnosis of cancer. Ongoing work to maintain awareness for patients and primary care of the diagnosis and emergency pathways is essential to optimize outcomes.
恶性脊髓压迫症(mSCC)是癌症最严重的并发症之一。最近的 NICE 指南旨在改善 mSCC 患者的患者路径和结果。我们研究了 NICE 指南实施后伦敦西部 mSCC 患者的当前表现、治疗和结果。
2012 年,在查令十字医院对所有经评估患有确诊或疑似 mSCC 的患者进行了电子病历和临床记录回顾。分析了转介数量、确诊 mSCC 的比例、癌症诊断、治疗和结局的详细信息。
共对 191 例患者进行了回顾,其中 127 例(66%)为确诊 mSCC。最常见的肿瘤类型是前列腺癌(26 例)、肺癌(26 例)、乳腺癌(21 例)和肾癌(15 例)。21%的患者无既往癌症诊断;mSCC 是他们的首发诊断事件。放射治疗是主要的治疗方法,24%的患者接受了一线手术治疗。在就诊时,62%的患者要么坐轮椅,要么卧床不起。治疗为所有患者群体带来了重要的活动能力改善,20%的最初坐轮椅或卧床不起的患者出院时具有独立活动能力。
增强患者的就诊路径,使患者能够更容易地获得治疗,快速评估和及时治疗可以改善结局。尽管有这些路径,许多患者仍表现出严重的运动障碍,超过 20%的患者没有先前的癌症诊断。为了优化结果,需要持续开展工作,以提高患者和初级保健医生对该疾病的认识,并优化紧急就诊路径。