Araki Toshimitsu, Okita Yoshiki, Uchino Motoi, Ikeuchi Hiroki, Sasaki Iwao, Funayama Yuji, Fukushima Kouhei, Futami Kitarou, Maeda Kiyoshi, Iiai Tsuneo, Itabashi Michio, Hase Kazuo, Motoya Satoshi, Kitano Atsuo, Mizushima Tsunekazu, Maeda Kotaro, Kobayashi Minako, Mohri Yasuhiko, Kusunoki Masato
Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan,
Surg Today. 2014 Jun;44(6):1072-8. doi: 10.1007/s00595-013-0809-9. Epub 2013 Dec 12.
A prospective, multicenter, observational study was performed to investigate the risk factors of surgical site infection (SSI) in patients with ulcerative colitis (UC).
From 2009 to 2010, perioperative clinicopathological data were collected from patients who had undergone surgery for UC within the research period, for up to 6 consecutive months in 13 hospitals in Japan. The primary outcome was the development of SSI.
A total of 195 patients with UC who underwent colorectal surgery were enrolled. SSI was diagnosed in 38 (19.5 %) patients, in the form of incisional infection in 23 (11.8 %), organ/space infection in 16 (8.2 %), and both in 1 (0.5 %). There were no significant risk factors associated with an increased risk of development of incisional SSI. An American Society of Anesthesiologists physical status of ≥ 3 was indicated as the only significant risk factor for organ/space SSI (P = 0.02) compared with other factors, such as a neutrophil count of >100 × 10(2)/mm(3), albumin level of <3.5 g/dl, perioperative packed red blood cell transfusion, fair or poor colonic cleanliness, and therapeutic use of antibiotics.
Poor general physical status was the significant independent risk factor for organ/space SSI in patients with UC in Japan.
进行一项前瞻性、多中心观察性研究，以调查溃疡性结肠炎（UC）患者手术部位感染（SSI）的危险因素。
2009年至2010年，收集了研究期间在日本13家医院接受UC手术患者连续6个月的围手术期临床病理数据。主要结局是发生SSI。
共纳入195例行结直肠手术的UC患者。38例（19.5%）患者被诊断为SSI，其中23例（11.8%）为切口感染，16例（8.2%）为器官/腔隙感染，1例（0.5%）两者皆有。没有发现与切口SSI发生风险增加相关的显著危险因素。与其他因素相比，如中性粒细胞计数>100×10⁹/mm³、白蛋白水平<3.5 g/dl、围手术期输注浓缩红细胞、结肠清洁度一般或较差以及抗生素的治疗性使用等，美国麻醉医师协会身体状况评分≥3被认为是器官/腔隙SSI的唯一显著危险因素（P = 0.02）。
在日本，UC患者中一般身体状况较差是器官/腔隙SSI的显著独立危险因素。
