50岁以下成年男性非心源性前循环卒中患者颅外颈动脉粥样硬化的生活方式因素患病率及相关性：一项为期一年的横断面研究。

Prevalence and association of lifestyle factors with extracranial carotid atherosclerosis in non-cardioembolic anterior circulation strokes in adult males less than 50 years: One year cross-sectional study.

作者信息

Hassan Kaukab M, Verma Aditya, Prakash Sudeep, Chandran Vijai, Kumar Suman, Banerji Anup

机构信息

Department of Internal Medicine, Division of Neurology, West Bengal University of Health Sciences, Alipore, India.

出版信息

Ann Indian Acad Neurol. 2013 Oct;16(4):516-20. doi: 10.4103/0972-2327.120448.

DOI:10.4103/0972-2327.120448

PMID:24339570

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3841591/

Abstract

BACKGROUND

Data is scarce on prevalence of extracranial carotid atherosclerosis (ECA) in strokes <50 years and its association with lifestyle factors.

OBJECTIVE

Study role of (a) ECA in non-cardio-embolic anterior circulation young strokes, and (b) smoking and alcohol in ECA.

MATERIALS AND METHODS

Cardiovascular risk factors and evidence of ECA on carotid doppler ultrasound (CDUS) was evaluated in an one-year preliminary cross-sectional study of consecutive strokes between 20 years and 49 years. Females were excluded.

RESULTS

There were 46 male strokes (mean age 38.26 yrs), 17.39% had hypertension, 2.23% had coronary artery disease; none was diabetic. Tobacco users and alcohol consumers were 24/46 (52.17%) cases each. ECA was found in 14/46 (30.44%) cases. Seven of these 14 (50%) i.e., 7/46 cases (15.21%) had carotid occlusion, four had <50%, three had >70% stenosis. 'Smoking and smokeless tobacco use' was found in 71.42% (10/14) symptomatic carotid lesions compared to 43.75% (14/32) strokes without carotid lesions. Prevalence odds ratio for tobacco use and ECA was 3.21 (95% CI: 0.83-12.44) while that of alcohol and ECA was 1.33 (95% CI: 0.38-4.72).

CONCLUSION

Prevalence of ECA in strokes <50 years was high due to lifestyle factors which predispose to atherosclerosis at younger age.

摘要

背景

关于50岁以下中风患者颅外颈动脉粥样硬化（ECA）的患病率及其与生活方式因素的关联的数据较少。

目的

研究（a）ECA在非心源性栓塞性前循环青年中风中的作用，以及（b）吸烟和饮酒在ECA中的作用。

材料与方法

在一项为期一年的对20岁至49岁连续中风患者的初步横断面研究中，评估了心血管危险因素以及颈动脉多普勒超声（CDUS）检查中ECA的证据。排除女性患者。

结果

共有46例男性中风患者（平均年龄38.26岁），17.39%患有高血压，2.23%患有冠状动脉疾病；无糖尿病患者。吸烟和饮酒者各有24/46（52.17%）例。14/46（30.44%）例发现有ECA。这14例中有7例（50%），即7/46例（15.21%）有颈动脉闭塞，4例狭窄小于50%，3例狭窄大于70%。在有症状的颈动脉病变中，71.42%（10/14）发现“吸烟和使用无烟烟草”，而在无颈动脉病变的中风患者中这一比例为43.75%（14/32）。吸烟与ECA的患病优势比为3.21（95%可信区间：0.83 - 12.44），而饮酒与ECA的患病优势比为1.33（95%可信区间：0.38 - 4.72）。