Wang Ying, Feng Yigang, Jia Yanbin, Xie Yanping, Wang Wensheng, Guan Yufang, Zhong Shuming, Zhu Dan, Huang Li
Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou, China ; Clinical Experimental Center, First Affiliated Hospital of Jinan University, Guangzhou, China.
PLoS One. 2013 Dec 10;8(12):e82682. doi: 10.1371/journal.pone.0082682. eCollection 2013.
Whether schizophrenia and bipolar disorder are the clinical outcomes of discrete or shared causative processes is much debated in psychiatry. Several studies have demonstrated anomalous structural and functional superior temporal gyrus (STG) symmetries in schizophrenia. We examined bipolar patients to determine if they also have altered STG asymmetry.
Whole-head magnetoencephalography (MEG) recordings of auditory evoked fields were obtained for 20 subjects with schizophrenia, 20 with bipolar disorder, and 20 control subjects. Neural generators of the M100 auditory response were modeled using a single equivalent current dipole for each hemisphere. The source location of the M100 response was used as a measure of functional STG asymmetry.
Control subjects showed the typical M100 asymmetrical pattern with more anterior sources in the right STG. In contrast, both schizophrenia and bipolar disorder patients displayed a symmetrical M100 source pattern. There was no significant difference in the M100 latency and strength in bilateral hemispheres within three groups.
Our results indicate that disturbed asymmetry of temporal lobe function may reflect a common deviance present in schizophrenia and bipolar disorder, suggesting the two disorders might share etiological and pathophysiological factors.
精神分裂症和双相情感障碍是由离散的还是共同的致病过程导致的临床结果，这在精神病学领域备受争议。多项研究已证实精神分裂症患者存在颞上回（STG）结构和功能的异常对称性。我们对双相情感障碍患者进行了检查，以确定他们是否也存在STG不对称性改变。
对20名精神分裂症患者、20名双相情感障碍患者和20名对照者进行了全脑磁脑图（MEG）听觉诱发电场记录。使用每个半球的单个等效电流偶极对M100听觉反应的神经发生器进行建模。M100反应的源位置用作功能性STG不对称性的指标。
对照者表现出典型的M100不对称模式，右侧STG的源更靠前。相比之下，精神分裂症患者和双相情感障碍患者均表现出M100源模式对称。三组双侧半球的M100潜伏期和强度无显著差异。
我们的结果表明，颞叶功能不对称性紊乱可能反映了精神分裂症和双相情感障碍中存在的共同偏差，提示这两种疾病可能共享病因和病理生理因素。
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