Gross M
Dtsch Med Wochenschr. 2013 Dec;138(51-52):2633-8. doi: 10.1055/s-0033-1359918. Epub 2013 Dec 16.
Ludwig van Beethoven suffered from various constitutional disorders, most publicly known his deafness. He died in 1827 from a decompensated liver cirrhosis. On his deathbed, admirers cut some ringlets from his head that can nowadays be used for scientific analyses. Hair analyses demonstrated that Beethoven was increasedly exposed to lead in his last 110 living days that may have contributed to the hepatic decompensation. The reason for the lead exposition was probably consumption of wines mixed with lead sugar, but also iatrogenic by lead-containing preparations administered for pneumonia in winter 1826/1827 as well as wound closure after puncturing for ascites four times.
路德维希·凡·贝多芬患有多种先天性疾病,其中最广为人知的是他的耳聋。他于1827年死于失代偿性肝硬化。在他临终时,崇拜者从他头上剪下了一些发卷,如今可用于科学分析。头发分析表明,贝多芬在生命的最后110天里接触铅的量不断增加,这可能导致了肝脏失代偿。铅暴露的原因可能是饮用了掺有铅糖的葡萄酒,但也可能是由于在1826年/1827年冬天因肺炎使用含铅制剂进行治疗,以及因腹水穿刺四次后伤口闭合而医源性接触铅。