Sun Yat-sen University Cancer Center, Guangdong, China; State Key Laboratory of Oncology in South China, Guangdong, China; Collaborative Innovation Center for Cancer Medicine, Guangdong, China.
Cancer Sci. 2013 Dec;104(12):1553-9. doi: 10.1111/cas.12287. Epub 2013 Nov 8.
Human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinomas (OPSCCs) frequently show different clinical and pathological features, which tend to be younger age, better performance status, less tobacco and alcohol consumption, more poorly differentiated histopathology, but usually with better treatment response and prognosis compared with HPV-negative OPSCCs. In tumor tissue, HPV infection is closely correlated with p16(INK4A) expression, which has been suggested to be a surrogate biomarker of HPV infection. However, there is diversity of sensitivity and specificity about p16(INK4A) in surrogate detection of HPV status. Herein, we summarize the current knowledge and note some aspects for consideration concerning p16(INK4A) as a surrogate biomarker for HPV-associated OPSCC.
人乳头瘤病毒（HPV）相关的口咽鳞状细胞癌（OPSCC）常表现出不同的临床和病理特征，这些特征通常表现为更年轻的年龄、更好的身体状态、更少的烟草和酒精摄入、更低的组织病理学分化程度，但与 HPV 阴性 OPSCC 相比，通常具有更好的治疗反应和预后。在肿瘤组织中，HPV 感染与 p16（INK4A）的表达密切相关，p16（INK4A）已被认为是 HPV 感染的替代生物标志物。然而，p16（INK4A）在 HPV 状态的替代检测中的敏感性和特异性存在多样性。在此，我们总结了目前的知识，并就 p16（INK4A）作为 HPV 相关 OPSCC 的替代生物标志物需要考虑的一些方面进行了说明。
