一名自出生即感染艾滋病毒的青年男性患疣状表皮发育不良——病例报告
Epidermodysplasia verruciformis in a young man with HIV since birth--case report.
作者信息
Meireles Sheila Itamara Ferreira do Couto, Andrade Sônia Maria Fonseca de, Lima Cristiano Luiz Horta de, Pires Mario Cezar
机构信息
Padre Bento de Guarulhos Hospital Complex, Dermatology Service, GuarulhosSP, Brazil.
Dermatology Service, Padre Bento de Guarulhos Hospital Complex, GuarulhosSP, Brazil.
出版信息
An Bras Dermatol. 2013 Nov-Dec;88(6 Suppl 1):190-2. doi: 10.1590/abd1806-4841.20132328.
Epidermodysplasia Verruciformis is a genodermatosis characterized by susceptibility to infection by specific HPV types (HPV 3/10 and beta-HPVs). It is considered to be the first model in human carcinogenesis induced by HPV. In this report we present a rare case of Epidermodysplasia Verruciformis associated with vertical transmission of HIV. Although most patients with HIV present infections by HPV virus, the frequency of Epidermodysplasia Verruciformis is no greater in patients with HIV because in EV there is a deficiency of specific cellular immunity to infection by some types of HPV, called HPV-related Epidermodysplasia Verruciformis.
疣状表皮发育不良是一种遗传性皮肤病，其特征是易感染特定类型的人乳头瘤病毒（HPV 3/10和β-HPVs）。它被认为是HPV诱导的人类致癌作用的首个模型。在本报告中，我们介绍了一例罕见的与HIV垂直传播相关的疣状表皮发育不良病例。尽管大多数HIV患者感染了HPV病毒，但HIV患者中疣状表皮发育不良的发生率并不更高，因为在疣状表皮发育不良中，针对某些类型HPV感染的特异性细胞免疫存在缺陷，称为HPV相关的疣状表皮发育不良。
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