Department of Clinical Medicine, Clinical Immunology Unit, Scleroderma Center, Sapienza University of Rome, Italy.
Department of Clinical Medicine, Nephrology Unit, Sapienza University of Rome, Italy.
Int J Immunopathol Pharmacol. 2013 Oct-Dec;26(4):1007-11. doi: 10.1177/039463201302600422.
Erectile dysfunction (ED) prevalence in male systemic sclerosis (SSc) is high and its pathogenesis is unclear. The aim of the study is to assess correlation between Doppler ultrasound indices of penis and kidneys or digital arteries in male systemic sclerosis. Fourteen men with systemic sclerosis were enrolled in this study. Erectile function was investigated by the International Index of Erectile Function-5. Peak systolic velocity, end diastolic velocity, resistive index, pulsative index, and systolic/diastolic ratio were measured on the cavernous arteries at the peno-scrotal junction in the flaccid state, on the interlobar artery of both kidneys and all ten proper palmar digital arteries. Ten (71 percent) patients have an International Index of Erectile Function-5 less than 21. Reduction of penis peak systolic velocity was observed in all SSc subjects. Doppler indices of cavernous arteries correlate with the International Index of Erectile Function-5. The renal and digital arteries resistive index demonstrated a good correlation (p less than 0.0001) with International Index of Erectile Function-5. A positive correlation exists between penis and kidney arteries Doppler indices: end diastolic velocity (p less than 0.05, r=0.54), resistive index (p less than 0.0001, r=0.90), systolic/diastolic ratio (p less than 0.01, r=0.69). A positive correlation was observed between penis and digital arteries Doppler indices: peak systolic velocity (p less than 0.01, r=0.68), end diastolic velocity (p less than 0.01, r=0.75), resistive index (p less than 0.001, r=0.79), systolic/diastolic ratio (p less than 0.05, r=0.59). A correlation exists between arterial impairment of penis and renal or digital arteries.
勃起功能障碍（ED）在男性系统性硬化症（SSc）中的患病率很高，其发病机制尚不清楚。本研究旨在评估男性系统性硬化症阴茎和肾脏或数字动脉的多普勒超声指数之间的相关性。本研究纳入了 14 名男性系统性硬化症患者。采用国际勃起功能指数-5 评估勃起功能。在疲软状态下，在阴茎阴囊交界处的海绵体动脉、双侧肾脏的叶间动脉和所有 10 个掌侧数字动脉上测量峰值收缩速度、舒张末期速度、阻力指数、搏动指数和收缩/舒张比值。10 名（71%）患者的国际勃起功能指数-5 小于 21。所有 SSc 患者的阴茎峰值收缩速度均降低。海绵体动脉的多普勒指数与国际勃起功能指数-5 相关。肾和数字动脉的阻力指数与国际勃起功能指数-5 具有良好的相关性（p 小于 0.0001）。阴茎和肾动脉多普勒指数之间存在正相关：舒张末期速度（p 小于 0.05，r=0.54）、阻力指数（p 小于 0.0001，r=0.90）、收缩/舒张比值（p 小于 0.01，r=0.69）。阴茎和数字动脉的多普勒指数之间存在正相关：峰值收缩速度（p 小于 0.01，r=0.68）、舒张末期速度（p 小于 0.01，r=0.75）、阻力指数（p 小于 0.001，r=0.79）、收缩/舒张比值（p 小于 0.05，r=0.59）。阴茎动脉损伤与肾或数字动脉之间存在相关性。
