儿童化疗引起脱发的临床特征。

Clinical characteristics of chemotherapy-induced alopecia in childhood.

机构信息

Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.

Division of Hematology/Oncology, Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.

出版信息

J Am Acad Dermatol. 2014 Mar;70(3):499-505. doi: 10.1016/j.jaad.2013.10.034. Epub 2013 Dec 16.

DOI:10.1016/j.jaad.2013.10.034

PMID:24355411

Abstract

BACKGROUND

Chemotherapy-induced alopecia (CIA) is a frequent complication in patients with cancer. There are an increasing number of reports of permanent CIA.

OBJECTIVE

We investigated the clinical characteristics of CIA, including permanent CIA in childhood.

METHODS

We collected data on 159 pediatric patients who had undergone high-dose conditioning chemotherapy followed by hematopoietic stem cell transplantation and 167 control subjects, using a questionnaire, medical record reviews, and phototrichograms.

RESULTS

Alopecia began at 1.5 ± 1.4 months and was sustained until 2.2 ± 1.6 months after chemotherapy initiation. Hair regrowth started 2.6 ± 1.6 months after chemotherapy ceased and lasted for 7.3 ± 4.9 months. The mean hair density and thickness were 198.3 ± 47.4/cm(2) and 76.3 ± 18.4 μm in the patient group and 229.6 ± 34.5/cm(2) and 79.5 ± 12.4 μm in the control group, respectively (both, P < .001). In all, 19 (12%) patients experienced permanent CIA. Thiotepa use was identified as a significant risk factor for permanent CIA (odds ratio 7.57, P = .002).

LIMITATIONS

Cross-sectional study in a single-center is a limitation.

CONCLUSION

CIA is common in pediatric patients. Use of thiotepa is strongly associated with permanent CIA.

摘要

背景

化疗引起的脱发（CIA）是癌症患者常见的并发症。越来越多的报道称 CIA 是永久性的。

目的

我们研究了 CIA 的临床特征，包括儿童期的永久性 CIA。

方法

我们使用问卷、病历回顾和毛发图收集了 159 名接受高剂量预处理化疗后行造血干细胞移植的儿科患者和 167 名对照者的数据。

结果

脱发于化疗开始后 1.5±1.4 个月开始，并持续至化疗开始后 2.2±1.6 个月。化疗停止后 2.6±1.6 个月开始毛发再生，持续 7.3±4.9 个月。患者组的平均毛发密度和厚度分别为 198.3±47.4/cm²和 76.3±18.4μm，对照组分别为 229.6±34.5/cm²和 79.5±12.4μm（均 P<.001）。共有 19 名（12%）患者发生永久性 CIA。噻替哌的使用被确定为永久性 CIA 的显著危险因素（比值比 7.57，P=.002）。