Sposato Luciano A, Fustinoni Osvaldo
Department of Clinical Neurological Sciences, London Health Sciences Centre, University of Western Ontario, London, Ontario, Canada.
INEBA Institute of Neurosciences, Buenos Aires, Argentina; Faculty of Medicine, University of Buenos Aires, Buenos Aires, Argentina.
Handb Clin Neurol. 2014;121:1635-71. doi: 10.1016/B978-0-7020-4088-7.00107-3.
Iatrogenic disease is one of the most frequent causes of hospital admissions and constitutes a growing public health problem. The most common type of iatrogenic neurologic disease is pharmacologic, and the central and peripheral nervous systems are particularly vulnerable. Despite this, iatrogenic disease is generally overlooked as a differential diagnosis among neurologic patients. The clinical picture of pharmacologically mediated iatrogenic neurologic disease can range from mild to fatal. Common and uncommon forms of drug toxicity are comprehensively addressed in this chapter. While the majority of neurologic adverse effects are listed and referenced in the tables, the most relevant issues are further discussed in the text.
医源性疾病是住院的最常见原因之一,并且构成了一个日益严重的公共卫生问题。医源性神经疾病最常见的类型是药物性的,中枢神经系统和周围神经系统尤其易受影响。尽管如此,在神经科患者的鉴别诊断中,医源性疾病通常被忽视。药物介导的医源性神经疾病的临床表现可从轻微到致命。本章全面探讨了常见和不常见的药物毒性形式。虽然大多数神经不良反应在表格中列出并引用,但最相关的问题在正文中会进一步讨论。